摘要
目的变应性鼻炎(allergic rhinitis,AR)与支气管哮喘关系密切,但关于AR患者下气道炎症国内仍缺乏研究。文中评估中重度持续性AR患者上、下气道嗜酸性粒细胞浸润水平及两者相关性。方法选取80名正常人(对照组)和101名单纯中重度持续性AR患者(AR组)行鼻灌洗及诱导痰涂片计数嗜酸性粒细胞个数。AR组鼻灌洗液及诱导痰嗜酸性粒细胞采用Pearson相关性分析结果 AR组鼻灌洗液与诱导痰涂片嗜酸性粒细胞水平均较对照组为高(P<0.01),AR组鼻灌洗液与诱导痰嗜酸性粒细胞之间存在相关性(r=0.31,P<0.01)。结论中重度持续性AR患者上、下气道嗜酸性炎症存在一致性。
Objective Although allergic rhinitis and asthma are closely related, there is still lack of research about the lower airway inflammatory condition of AR patients. The aim of this study is to evaluate the eosinophils in upper and lower airway in patients with moderate/severe persistent allergic rhinitis. Methods 80 health adults and 101 patients with moderate/severe persistent AR participated the nasal lavage test and induced sputum. Results The eosinophils of upper airway in the AR group is statistically higher than the control group （ P 〈 O. 01 ）, and the eosinophil of induced sputum in the former group is significantly higher than the nor- mal group （t = -5. 648, P 〈 O. O1 ） ; The eosinophil levels of nasal lavage were related to the sputum induction （r = O. 31, P 〈 O. O1 ）. Conclusion The AR group shows significantly higher level of eosinophil than the control group, not only in upper airway, but also lower airway, the inflammation of ureter and lower airway correlateds.
出处
《医学研究生学报》
CAS
北大核心
2013年第4期367-369,共3页
Journal of Medical Postgraduates
基金
呼吸疾病国家重点实验室开放课题(2007DA780154F0907)
