摘要
目的通过对中重度持续性变应性鼻炎(persistent allergic rhinitis,PAR)患者下气道炎症相关指标的研究,了解AR对下气道影响的特征及程度。方法选择2010年6月～2011年12月在我科就诊的101例中重度PAR患者,以及80名正常人,采用支气管激发试验和诱导痰检查对下气道炎症进行评价。结果中重度PAR支气管激发实验阳性率为14.9%(15/101)),与对照组2.5%(2/80)相比,采用χ2检验,差异有统计学意义(χ2=8.003,P<0.05),AR组存在明显的气道高反应性;采用独立样本t检验,前者诱导痰嗜酸细胞百分比为(5.51±9.11)%,明显高于正常对照组的(0.81±1.44)%(t=-5.648,P<0.01),两组间差异有显著统计学意义。结论中重度PAR患者下气道较正常人呈现明显的气道高反应性及嗜酸性粒细胞浸润水平,上气道炎症对下气道存在影响。
OBJECTIVE To assessment the bronchial hyperresponsiveness and inflammation status in patients with moderate/severe persistent allergic rhinitis by bronchial provocation test and induced sputum examination. METHODS There were 80 normal subjects and 101 patients with moderate/severe persistent AR participated the bronchial provocation test and induced sputum examination on the basis of allergen skin prick test and nasal smears. RESULTS The positive rate of bronchial provocation test in the AR group was 14.9% （15/101） , which was statistically higher than that in control group （2.5%, 2/80） using chi-square test （X^2=8.003, P〈0.05）. The AR group existed significant airway reactivity. The eosinophil percentage of induced sputum in the AR group [ （5.51 ±9.11） %] was significantly higher than that in normal group[ （0.81 ± 1.44） %, t=-5.648, P〈0.01].CONCLUSION The AR group shows significantly higher level of bronchial hyperresponsiveness and higher eosinophil percentage than that in normal group. That means the inflammation of upper airway affects the lower airway.
出处
《中国耳鼻咽喉头颈外科》
CSCD
2013年第2期61-64,共4页
Chinese Archives of Otolaryngology-Head and Neck Surgery
基金
呼吸疾病国家重点实验室开放课题(2007DA780154F0907)
关键词
鼻炎
变应性
常年性
支气管激发试验
嗜
酸细胞
诱导痰
Rhinitis, Allergic, Perennial
Bronchial Provocation Tests
Eosinophils
induced sputum
