摘要
尖锐湿疣(CA)是感染人乳头瘤病毒(HPV)引起的一种常见的性传播疾病(STD)。鬼臼毒素能抑制细胞增殖,以鬼臼毒素为主药的制剂在临床已应用多年,疗效肯定。当前应用于临床的鬼臼毒素剂型主要是软膏、酊剂、凝胶剂等,而纳米载药新剂型,如脂质体、微乳凝胶、固体脂质纳米粒、醇质体、纳米脂质载体等仍处于实验室研究阶段,但其具有对皮肤、黏膜靶向性好、刺激性小、系统吸收少等优点。
Condyloma Acuminatum （CA） is a common sexually transmitted disease （STD）, which caused by the infec-tion of Human Papillomavirus （HPV）. Podophyllotoxin （POD） can inhibit cell proliferation, and the prepa-ration contained POD has been used in clinical for many years. The formulations of POD in actual use are ointment, tincture and gels. And the POD-loaded nano-preparation carriers, such as liposomes, micro emul-sion gel, solid lipid nanoparticle （ SLN）, ethosomes, nanostructured lipid carrier （NLC） are still in the stage of laboratory research, while it has better skin and mucous membrane-targeting, less stimulus, and less systemic absorption.
出处
《中国皮肤性病学杂志》
CAS
北大核心
2013年第5期524-525,534,共3页
The Chinese Journal of Dermatovenereology
基金
国家自然科学基金项目(81171627)
广东省教育厅科技创新重点项目(cxzd1119)
关键词
鬼臼毒素
尖锐湿疣
剂型
Podophyllotoxin
Condyloma acuminate
Formulations
