摘要
患者女,51岁。左侧颞部浅棕色斑疹20年,其上出现棕褐色丘疹1个月,无不适。皮损组织病理示:表皮角化过度,棘层肥厚,乳头瘤样增生,伴角囊肿、假性角囊肿的形成;角质层内可见黑素颗粒,黑素细胞散在分布于表皮各层,黑素细胞水平扩展,真、表皮界限不清;真皮内未见明显色素细胞巢,见淋巴细胞浸润。免疫组化示:HMB45和S-100蛋白(+),CK(+/-)。诊断:脂溢性角化病;原位黑素瘤。
A 51-year-old female presented with a light brown macula on her left temporal region 20 years ago, and ap-peared a chocolate brown papule on the maeula for a months, with non - symptom. Histopathology showed hyperkeratosis, acanthosis, papillomatous hyperplasia, keratin cyst and pseudohorn cysts. Melanin granule were found in the stratum corneum, and melanocvtes seattered horizontally in each layer of epidermis. Epi-dermis and dermis was no clear boundary, and igment cell nests were not seen in the dermis, with lympho-cyte infiltration, lmmunohistochemistry staining showed： S-100 protein（ ＋ ） , HMB45 （ ＋ ）, CK （ ＋/- ）. Diagnosis： seborrheic keratosis and melanoma in situ.
出处
《中国皮肤性病学杂志》
CAS
北大核心
2013年第5期511-512,共2页
The Chinese Journal of Dermatovenereology
