摘要
蛋白C是一种存在于血液中的维生素K依赖性糖蛋白酶,在凝血酶-血栓调节蛋白(T-TM)复合物作用下活化为活化蛋白C(APC)。APC是重要的抗凝因子之一,具有抗炎、抗凋亡及保护内皮屏障等作用。研究证实,APC与多种疾病相关,本文重点阐述APC与糖尿病肾病之间的关系。
Protein C （PC）is a vitamin K-dependent glyeoprotein and circulates in plasma. Activated protein C （APC） is generated when thrombin-thrombomodulin complex activates protein C. Besides its important anticoagulant role, APC exerts multiple functions including anti-inflammatory activities, antiapoptotie activity and protection of endothelial barrier effect. A lot of studies revealed that APC was associated with diverse diseases. This review emphasizes the relationship between APC and diabetic nephropathy.
出处
《肾脏病与透析肾移植杂志》
CAS
CSCD
北大核心
2013年第2期145-148,共4页
Chinese Journal of Nephrology,Dialysis & Transplantation
关键词
活化蛋白C
细胞保护作用
变异体
糖尿病肾病
activated protein C cytoprotective effects variant diabetic nephropathy
