摘要
目的 :探讨内皮素 (ET)与心钠素 (ANP)在高血压发病和治疗学中的意义。方法 :6 0例原发性高血压 (EH)患者口服依那普例 5～ 1 0 mg/d或阿罗洛尔 2 0～ 30 mg/d,疗程为 6周 ,放免法测定治疗前后血浆 ET和 ANP水平。结果 :EH患者血 ET、ANP水平明显高于对照组 (P<0 .0 5 ) , 期高血压患者血 ET水平高于 期 (P<0 .0 1 ) ,ANP的变化与分期无关 (P>0 .0 5 )。治疗后 ,两组患者血压明显下降 (P<0 .0 1 )。依那普利组患者血 ET、 ANP水平均下降 ,阿罗洛尔组血 ET水平没有变化 (P>0 .0 5 ) ,而 ANP水平升高 (P<0 .0 1 )。结论 :ET、ANP在高血压发病中起重要作用 。
Aim:To explore the significance of endothelin(ET)and atrial natriuretic peptide(ANP) in the pathogenesis and therapy of essential hypertension(EH). Methods:Enalapril 5～10 mg/d or arotinolol 20～30 mg/d were given to 60 cases of hypertension. Plasma levels of ET and ANP were measured by radiommunoassay before and after 6 weeks treatement. Results:Before treatment,EH subjects had higher levels of ET and ANP( vs control group, P< 0 05). The levels of ET in phase Ⅱ hypertension was higher than that in phase Ⅰ( P< 0 05). The levels of ANP had no significance difference between phaseⅠorⅡ. After six week treatement,blood pressure was decreased( P< 0 01). In arotinolol group,the levels of ET didn't change( P> 0 05), however ANP increased( P< 0 01). Conlusion:ET and ANP play an important role in the pathogenesis of EH.
出处
《高血压杂志》
CSCD
2000年第3期227-229,共3页
Chinese Journal of Hypertension
关键词
高血压
依那普利
阿罗洛尔
治疗
内皮素
心钠素
essential hypertension
endothelin
Atrial natriuretic
enalapril
arotinolol.
