摘要
１２２例轻，中度原发性高血压患者分为两组，予口服阿罗洛尔（ａｒｏｔｉｎｏｌｏｌ，ａｌｍａｒｌ）或对照药阿替洛尔（ａｔｅｎｏｌｏｌ）。以随机、双盲对照法，对其疗效及不良反应进行了研究。阿罗洛尔组依次递增剂量１０－１５ｍｇｂｉｄ，４周后平均坐位血压由治疗前２１．８／１３．４ｋＰａ（１６３．７／１００．７ｍｍＨｇ）降至１９．７／１１．９ｋＰａ（１４８．１／８９．１ｍｍＨｇ），总有效率为７６％，１０ｍｇｂｉｄ，显效率为７２．１％。阿替洛尔组依次递增剂量为１２．５－２５ｍｇｂｉｄ，４周后平均坐位血压由治疗前的２１．８／１３．４ｋＰａ（１６３．５／１００．４ｍｍＨｇ）降至１９．５／１１．７ｋＰａ（１４６．１／８７．９ｍｍＨｇ）总有效率为８０％，１２．５ｍｇｂｉｄ，显效率为６９．２％。两组间临床疗效无显著性差异。两组日服二次法，均可较平稳地控制２４ｈ血压，保持时辰节律。两组中常见不良反应为头晕、失眠及乏力，在继续服药中，逐渐减轻，部分症状消失，两组均无因不良反应而退出试验者。两组实验室检查无明显异常。２０例服阿罗洛尔治疗半年的患者，疗效保持稳定，实验室检查及体重亦未发现明显异常。结果表明，阿罗洛尔的临床疗效和药物不良反应?
Arotinolol,a new beta-alpha adrenoceptor blocker, is effective in the treatment of essential hypertension. The antihypertensive effects and safety profiles of arotinolol (10-15mg) and atenolol(12.5-25mg) twice daily were compared in a randomized,double-blind parallel group clinical trial in 122 patients with mild to moderate essential hypertension. After 4 weeks of therapy, arotinolol reduced mean sitting systolic blood pressure (SBP) from 163.7 mmHg to 148.1 mmHg.Sitting diastolic blood pressure (DBP) was reduced from 100.7 mmHg at baseline to 89.1 mmHg.Atenolol reduced mean SBP from 163.5 to 146.1 mmHg and mean DBP from 100.4 to 87.9 mmHg. There was not significant difference in the percentage of responders between arotinolol and atenolol group (76% vs 80% ) . There were 50% responders to the dosed 10 mg twice daily in arotinolol group,and 45% responders to the dosed 12.5 mg twice daily in atenolol group. The antihypertensive effect of arotinolol and atenolol twice daily both could persist for over 24 hours.The commonest adverse effects in the two groups were insomnic, dizziness and chest depression. No patient withdrew from the treatment because of adverse reactions.No abnormal laboratory results were recorded in either group. There were 20 patienls whose blood pressure, heart rate, haernatological and biochemical tests remained within normal limits after 6 months treatmetnt with arotinolol.In conclusion the clinical effects and tolerability of arotinolol are the same as atenolol. Compared with the placebo arotinolol twice daily could satisfactorily reduce ambulatory blood pressure for over 24 hours.Arotinolol is well tolerated by Chinese patietns with mild-to-moderate hypertension as shown in this study.
出处
《中国临床药理学杂志》
CAS
CSCD
北大核心
1996年第3期136-141,共6页
The Chinese Journal of Clinical Pharmacology
关键词
原发性
高血压
阿罗洛尔
阿替洛尔
arotinolol
atenolol
essential hypertension
randomized controlled
