摘要
目的 采用前瞻随机分组研究 ,探讨野中野加速超分割放疗能否提高胸段食管癌的疗效。方法 1992年6月至 1993年 12月 ,6 9例胸段食管癌随机分组 ,野中野加速超分割治疗组 34例 ,常规治疗组 35例 ,两组患者一般临床资料差异无统计学意义。放射总剂量常规组 6 5Gy± 2 .1Gy ,照射 33次 /45天 ,野中野组总剂量 6 5Gy± 1.6Gy ,2 3次 /34天。结果 急性放射性食管炎发生率常规组 17% ,野中野组 38%。常规组 1、3、5年生存率分别为 :5 1.4%、2 0 %、14 .3 % ,而野中野组分别为 70 .5 %、44.12 %、2 6 .5 % (3年生存率差异显著P <0 .0 5 )。结论 野中野加速超分割放疗胸段食管癌患者可耐受 ,并且提高了长期生存率。
Objective To evaluated the effects of accelerated hyperfraction radiotherapy by field in field for middle esophageal carcinoma.Methods From June,1992 to December,1993,69 patients with middle esophageal carcinoma were randomized into two groups:conventional fraction radiation(CFR) group(35cases) and accelerated hyperfraction radiotherapy by field in field(FIF)group(34cases).There was no significant difference about clinical characteristics between two grorps.65Gy±1.6Gy/f23fx/32days were given to FIF group.Results The acute esophagitis was more frequently seen in FIF group than in CFR group (38% vs 17%).The survival rates of 1,3 and 5 year were 51.4%,20% and 14.3% in CFR group,and 70.5%,44.1% and 26.5% in FIF group,respectively (3 year survival was significantly different between two grorps P<0.05).Conclusions Accelerated hyperfraction radiotherapy by field in field can be tolerated by most patients with esophageal carcinoma which has achieved better long term results. [
出处
《中国肿瘤临床与康复》
2000年第5期36-37,共2页
Chinese Journal of Clinical Oncology and Rehabilitation
关键词
食管癌
野中野加速超分割放疗
治疗
胸段
esophageal carcinoma
accelerated hyperfraction radiotherapy by field in field.
