摘要
目的:探讨新生儿缺血缺氧性脑病(HIE)采用头部亚低温治疗的效果及安全性。方法:选取该院于2012年经头部MRT或CT确诊为HIE的足月儿48例为研究对象,随机将患儿分为常规治疗(对照组)24例以及选择性头部亚低温治疗(观察组)24例。两组患儿均采取维持血压、血糖,稳定内环境,维持水电解质平衡,降低颅内压力,给予氧气支持,解痉镇静等综合性治疗,观察组患儿于出生6 h内给予头部低温治疗,并于治疗后72h再对患儿头部复温。对比分析两组患儿治疗前、中、后神经系统症状发生情况,并于治疗第7天、第14天、第28天对两组患儿进行神经行为功能(NBNA)评分。结果:观察组患儿治疗后神经症状发生率低于对照组,而治疗后NBNA评分显著高于对照组,差异有统计学意义(P<0.05)。结论:新生儿缺血缺氧性脑病采用选择性头部亚低温治疗可起到保护神经功能的作用,安全可靠,远期治疗效果理想,值得临床应用。
Objective： To investigate the efficacy and safety of head mild hypothermia on the treatment of neonatal hypoxic - ische- mic encephalopathy （HIE） . Methods： 48 cases of HIE from January 2012 to January 2013 were selected for the study, and 24 cases of conventional treatment （control group） and 24 cases of selective head mild hypothermia treatment （observation group） . Children in the two groups of were taken to maintain the blood pressure, blood sugar, stable internal environment, water electrolyte balance, reduce intracranial pressure, and given Oxygen support and antispasmodic and sedative treatment. Children of observation group in 6 h after birth were given head hypothermia treatment, 72 h later treated with head rewarming. Comparision of the nervous system symptoms of the two groups before, during and after treatment was made, children of the two groups were treated with neurobehavioral function （NBNA） on the 7th, 14th, 28th day of the treatment. Results： The incidence of neurological symptoms of the observation group was lower than that of the control group after treat- ment, and the NBNA score significantly was higher than that of the control group. The difference was statistically significant （P 〈 0. 05） ~ Conclusion： The neonatal HIE selective head hypothermia therapy could play a role in protecting the nerve function, with wholiy reliable, ideal long - term treatment effects, which is worthy of clinical application.
出处
《中国妇幼保健》
CAS
北大核心
2013年第13期2083-2085,共3页
Maternal and Child Health Care of China
基金
贵州省贵阳市人民医院科研课题〔280076〕
关键词
新生儿
缺血缺氧性脑病
亚低温
行为神经评分
Neonatus
Hypoxic ischemic encephalopathy
Mild hypothermia
Behavioral neuroscience ratings
