摘要
目的探讨早期乳腺癌保乳手术联合术中放疗的临床疗效。方法 120例早期乳腺癌患者随机分为观察组与对照组,每组各60例,观察组患者采用手术+术中放疗治疗,对照组患者给予手术+术后常规放疗治疗,观察两组治疗效果。结果观察组患者切口愈合时间显著长于对照组(P<0.01),观察组术后切口水肿、脂肪液化等并发症的发生率显著高于对照组(P<0.01);术后1年乳房美容效果比较,观察组患者优良率为85.0%,显著高于对照组的63.3%(P<0.01);随访过程中,观察组患者局部复发2例(3.3%),死亡1例(1.7%);对照组患者复发1例(1.7%),无死亡病例,两组复发率及死亡率比较,差异无统计学意义(P>0.05)。结论手术+术中放疗在早期乳腺癌患者中具有良好效果,同时避免了全乳放疗导致的局部第二原发肿瘤,且可获得更好的美容效果,但临床应用中需注意对术后切口愈合的影响。
Objective To study the clinical effects of intra-operative radiotherapy （IORT） com- bined with breast-conserving surgery （BCS） in patients with early breast cancer. Methods 120 patients with early breast cancer were randomly devided into the observation group （n = 60） and the control group （n =60）, the observation group were treated with IORT combined with BCS, and the control group were trea- ted with BCS and routine postoperative radiotherapy, then the clinical effects were contrasted between the two groups. Results The wound healing time of the observation group was significantly longer than the con- trol group（ P 〈0.01 ） ; Incidence of postoperative edema, fat liquefaction and other complications in the ob- servation group was significantly higher than the control group （ P 〈 0.01 ） ; the excellent rate of postoperative cosmetic results in the observation group（85.0% ） was significantly higher than the control group（63.3% ） （P 〈 O. O1 ）; recurrence rate in the observation group was 3.3%, mortality 1.7%, and recurrence rate 1.7% in the control group without deaths. Conclusions BCS ＋ IORT has good effects in patients with ear- ly breast cancer, Avoided the partial second primary tumor because of the whole breast radiotherapy, and better cosmetic results can be obtained, but should pay attention to the incision healed.
出处
《中国肿瘤临床与康复》
2013年第4期380-382,共3页
Chinese Journal of Clinical Oncology and Rehabilitation
关键词
早期乳腺癌
保乳手术
术中放射治疗
Early breast cancer
Breast-conserving surgery
Intra-operative radiotherapy
