摘要
目的：探讨术后早期应用肠内高营养治疗对晚期胃癌患者白细胞介素（IL）-2系统水平的影响。方法：98例晚期胃癌术后患者随机分成早期肠内高营养组和常规输液对照组，采用酶联免疫吸附测定（ELISA）等方法检测两组患者治疗前后的外周血清IL－2、IL－2受体（IL－2R）α及可溶性IL－2R（sIL－2R）水平。结果：早期肠内高营养组患者冶疗1周后，机体IL－2和IL－2Rα水平较治疗前显著上升，sIL－2R水平明显下降（治疗前：IL－224.83U／ml±2.10U／ml，IL－2Rα17.8％±2．8％，sIL－2R347．9U／ml±57．8U／ml，治疗后：IL－279．82U／ml±6．88U／ml，IL－2Rα27．5％±4．0％，sIL－2R157．9U／ml±24．3U／ml）；而常规输液对照组患者的IL－2水平较治疗前呈下降趋势，IL－2Rα和sIL－2R水平变化不明显（治疗前：IL－221.87U／ml±1．98U／ml，IL－2Rα18．3％±3.8％，sIL－2R479．3U／ml±69．8U／ml；治疗后：IL－211．34U／ml±0．89U／ml，IL－2Rα17．4％±2．7％，sIL－2R481．2U／ml±70.4U／ml），两组治疗后结果相比有显著差异。结论：早期应用肠内高营养治疗晚期胃癌术后患者，有利于尽快恢复患者的机体免疫调节功能，为今后临床开展该项治疗提供了证据。
Background/Aims: To study the effects of early enteral hyperalimentation therapy on interleukin (IL)-2 system of postoperative advanced gastric cancer patients. Methods : 98 postoperative advanced gastric cancer patients were randomly divided into two groups, early enteral hyperalimentation group and routine intravenous infusion group. Serum IL-2, IL-2 receptor (IL-2R) α and soluble IL-2R(sIL-2R) levels in both groups were measured by enzyme-linked immunosorbent assay (ELISA). Results:ln early enteral hyperalimentation group IL-2 and IL-2R7 levels were increased markedly and sIL-2R level was decreased after one-week treatment (before treatment: IL-2 24.83 U/ml ± 2.10 U;/ml, IL-2Rα17.8% ± 2.8%, sIL-2R 347.9 U/ml ± 57.8 U/ml; after treatmentt IL-2 79.82 U/ml± 6.88 U/ml, IL-2Rα 27.5%± 4.0%, sIL-2R 157.9 U/ml±24.3 U/ml), while in the routine intravenous infusion group there was a decrease in IL-2, but no changes in IL-2R7 and sIL-2R levels (before treatment: IL-2 21.87 U/ml ±1.98U/ml, IL-2Rα 18.3% ±3.8%, sIL-2R 479.3 U/ml±69.8 U/ml, after treatmentt IL-2 11.34 U/ml±0.89 U/ml,IL-2Rα17.4% ±2.7%, sIL-2R 481.2 U/ml ±70.4 U/ml). Significant differences were found in IL-2, IL-2Rαand sIL-2R levels between the two groups after one-week treatment. Conclusions: Early enteral hyperalimentation therapy is helpful in restoration of the immuno-modulating function of postoperative advanced gastric cancer patients.
出处
《胃肠病学》
2000年第3期156-157,共2页
Chinese Journal of Gastroenterology
关键词
胃肿瘤
肠营养
白细胞介素2
受体
Stomach Neoplasms, Enteral Nutrtion
Interleukin-2, Receptors, Interleukin-2
