摘要
检测了３株分化不同的人胃癌细胞ＭＫＮ－４５、ＭＫＮ－２８、ＳＧＣ－７９０１在体外培养过程中产生免疫抑制因子的体外免疫抑制作用，分化差的ＭＫＮ－４５及源于转移性ＳＧＣ－７９０１胃癌细胞株体外培养过程中产生免疫抑制因子对正常人外周血单个核细胞（ＰＢＭＣ）产生ＩＬ－２水平及其ＩＬ－２Ｒ表达抑制作用较强，且显著高于高分化ＭＫＮ－２８细胞株产生免疫抑制因子的作用；而正常ＲＰ－ＭＩ１６４０细胞培养液无免疫抑制作用。这一研究结果表明：胃癌细胞本身可自行分泌免疫抑制物质或因子，同时提示胃癌患者机体免疫功能低下不仅与体内免疫抑制细胞有关，而且与胃癌细胞本身产生免疫抑制因子不可分割。
upernatants of MKN45,MKN28,SGC7901,three gastric cell lines of varying differentiaion were proved to have immune inhibitory factors in vitro.Inhibitory rates of three different supernatants for normal interleukin2 production were 89.40%,85.77% and 95.04% respectively. For interleukin2 receptor expression were 41.36%,23.82% and 27.16% respecptively. In particular,supernatants of lower differentiation cells MKN45 and SGC7901 were obviously more inhibitory than that of MKN28.These results suggested cellular immune defect was not only associated with suppressor cells(CD8+),but also immune inhibitory factors from gastric cancer cells as an autocrine secretion might also play an important rule.
出处
《中国免疫学杂志》
CAS
CSCD
北大核心
1998年第3期201-203,共3页
Chinese Journal of Immunology
