摘要
目的探讨前列地尔注射液对增殖前期糖尿病视网膜病变(preproliterative diabetic retinopathy,PPDR)激光光凝术后的治疗效果。方法选择2010年7月—2012年6月我院门诊及住院的增殖前期糖尿病视网膜病变患者62例(89眼)。将其随机分为治疗组和对照组,其中对照组30例(45眼),治疗组32例(44眼)。对照组给予全视网膜光凝治疗;治疗组在上述治疗后加用前列地尔10μg静脉注射,1次/d,2～3周。观察治疗前后患者视力、黄斑水肿、眼底血管造影的变化情况。结果治疗组视力提高有效率为93.2%,高于对照组的82.2%,差异有统计学意义(P<0.05)。治疗组眼底新生血管、微血管瘤及黄斑水肿吸收消退有效率77.3%,高于对照组的53.3%,差异有统计学意义(P<0.05)。结论增殖前期糖尿病视网膜病变激光光凝术后使用前列地尔比单纯激光光凝治疗更有效。
Objective To investigate the effect of Prostaglandin E1 Injection to Acute preproliterative diabetic retinop- athy after laser photocoagulation. Methods 62 patients （89eyes） in our hospital and out - patients were Choose from July 2010 to June 2012 who diagnosed with preproliterative diabetic retinopathy. They were randomly divided into the therapeutic group （30 cases 45eyes） and the control group （32 cases 44eyes）, The control group was treated with panretinal photoeoagulation （PRP）. the therapeutic group was accepted alprostadil injection after laser photoeoagulation, Observe the change of vision, macula edema and fundus fluorescent angiography before and after treating. Results The rate of sight raised was 93.2% in therapeutic group, higher than 82. 2% in control group （P 〈 0. 05 ） , the rate of Retinal neovaseularization, retinal mieroanearysmmaeular and macula edema disappeared was77. 3% in therapeutic group, higher than 53. 3% in control group （P 〈0. 05）. Conclusion The Prostaglandin E1 Injection to Acute preproliterative diabetic retinopathy after laser photocoagulation may achieve a better ef- ficacy than simple laser photocoagulation.
出处
《临床合理用药杂志》
2013年第12期42-43,共2页
Chinese Journal of Clinical Rational Drug Use
关键词
糖尿病
视网膜
前列地尔
激光光凝术
Diabetes mellitus
Retina
Prostaglandin E1
Laser photocoagulation
