摘要
目的采用偱证医学Meta分析的方法以探讨心理干预对鼻咽癌患者焦虑抑郁症状的影响。方法计算机检索万方、维普、CNKI及中国生物医学等中文数据库,全面收集有关心理干预对鼻咽癌患者焦虑抑郁症状的影响临床对照试验,汇总数据采用RevMan5.1.6和Stata12.0进行分析,两组之间差异采用标准均数差(SMD)或优势比(OR)及其95%可信区间(95%CI)描述。结果严格根据纳入和排除标准,最终纳入6个临床对照试验,包括724例鼻咽癌患者,其中观察组361例,对照组363例。Meta分析结果表明:治疗前,心理干预组与对照组患者抑郁症状SDS评分和焦虑症状SAS评分均无明显差异(分别为SMD=0.10,95%CI=-0.07～-0.27,P=0.27;SMD=0.01,95%CI=-0.17～-0.20,P=0.88);治疗后,心理干预组患者SDS评分和焦虑症状SAS评分显著低于对照组患者,两组之间差异有统计学意义(分别为SMD=-1.05,95%CI=-1.56～-0.54,P<0.00001;SMD=-1.34,95%CI=-2.18～-0.50,P=0.002)。结论现有证据表明,心理干预可有效地改善鼻咽癌患者的焦虑抑郁症状。由于纳入研究质量及数量有限,本研究结论尚需大样本高质量临床研究进行证实。
Objective This study aims to investigate the influence of psychological intervention on the anxiety and depressive symptoms for patients with nasopharyngeal cancer by conducted a systematic review and meta-analysis. Methods Wanfang, CNKI, VIP and CBM databases were searched extensively to identify relevant clinical controlled trials. Data were analyzed by RevMan 5. 1.6 and Stata 12. 0 softwares. Results were described as Standardized mean difference （SMD） or odds ratio （OR） with 95% confidence intervals （CI）. Results Finally, a total of 6 clinical controlled trials involving 724 nasopharyngeal cancer patients were includ- ed in this systematic review,including 361 patients in observation group and 363 patients in control group. Meta-analysis showed that there was no significant difference between two groups in pre-intervention SDS scores （SMD = 0. 10,95% CI = -0. 07 - -0. 27 ,P = 0. 27 ） and pre-intervention SAS scores （ SMD = 0. 01,95% CI = - 0. 17 - - 0. 20, P = O. 88 ）. However, post-intervention SDS scores （SMD = - 1.05,95% CI = - 1.56 - -0. 54,P 〈0. 00001 ） and post-intervention SAS scores （SMD = - 1.34,95% CI = -2. 18 -0. 50 ,P = O. 002） had statistically significant differences. Conclusion The present data suggests that psychological intervention may relieve anxiety and depressive symptoms for patients with nasopharyngeal cancer. Further well-designed randomized controlled trials are needed to confirm or adjust current conclusions.
出处
《中国老年保健医学》
2013年第2期27-30,共4页
Chinese Journal of Geriatric Care
关键词
心理干预
鼻咽癌
焦虑抑郁症状
临床对照研究
META分析
psychological intervention
nasopharyngeal cancer
anxiety and depressive symptoms
clinical controlled trials
meta-analysis
