摘要
老年性痴呆(Alzheimer disease,AD)是一种中枢神经系统退行性病变。由于发病机制复杂,至今其病因不明,制约了该病动物模型的制作研究工作。但随着社会老龄化问题日益严重,老年痴呆相关机制和治疗成了热点和难点,关于老年痴呆动物模型的研究也越来越多样和深入。本文总结了近几年来国内外对老年痴呆动物模型的研究进展发现,转基因与复合型动物模型已逐渐成为研究趋势。
Senile dementia （Alzheimer disease, AD） is a kind of age related with the central nervous system of the degene- rative diseases. Due to the pathogenesis complex, so far the unknown etiology, restrains the research work of animal models of production for this disease. With the aging society becomes more and more serious, al^eimer ＇s-related mechanism and treatment become a hot and difficult, and the study about dementia animal model is also more and more diverse and deeper. This paper summarizes the progress both at home and abroad in recent years in alzheimer＇s animal model research, and gen- etically modified and complex animal model have gradually become the research tendency.
出处
《科教导刊》
2013年第7期159-161,共3页
The Guide Of Science & Education
关键词
老年性痴呆
动物模型
研究进展
senile dementia
animal model
research progress
