摘要
目的:观察皮肤创面无机诱导活性敷料治疗咽喉癌放疗后颈部皮肤损伤的疗效。方法:将咽喉癌放疗后颈部皮肤损害Ⅱ级以上患者随机分成试验组与对照组,各38例。先用5%聚维酮碘对创面进行常规外科消毒,无菌注射器抽取水疱内渗液,无菌剪刀剪去破溃水疱的表皮,彻底清除坏死组织,再用0.9%氯化钠溶液冲洗创面,5%聚维酮碘进行常规外科消毒。试验组将皮肤创面无机诱导活性敷料粉末均匀撒布于皮肤创面;对照组将莫匹罗星软膏均匀涂抹于皮肤创面。最后用单层消毒凡士林纱布覆盖创面,再覆盖消毒纱布,以胶带或绷带固定,每日1次。比较两组患者治疗2周后临床疗效、化疗时间、住院时间及住院费用的差异。结果:试验组总有效率(92.11%)显著高于对照组(73.68%),差异有统计学意义(χ2=4.547,P=0.033)。试验组化疗时间、住院时间和住院费用分别为(33.72±4.12)d、(40.49±5.13)d、(2.63±0.27)万元,显著低于对照组的(37.58±4.56)d、(43.35±5.40)d、(2.86±0.32)万元,差异均有统计学意义(P<0.05)。结论:皮肤创面无机诱导活性敷料治疗咽喉癌放疗后颈部皮肤损伤疗效显著,有利于患者继续接受放疗、减少住院时间和降低住院费用。
OBJECTIVE ： To observe therapeutic efficacy of dermlin in the treatment of skin injury of the neck in throat cancer patients accepted radiotherapy. METHODS： Throat cancer patients suffering from class I1 to 1V skin injury of the neck after radiotherapy were randomly divided into trial group and control group with 38 cases in each group. Routine surgical sterilization on wound surface was conducted using 5% povidone iodine ketone, and then extracted the exudate of blister using sterile syringes, the epidermis of the broken blister were cut off, and necrotic tissue was cleaned. 0.9% sodium chloride solution flushed wound surface, and routine surgical sterilization on wound surface was conducted using 5 % povidone iodine ketone. In trial group, dermlin were spread on the wound surface evenly; in control group, Mupirocin ointment were spread on wound surface evenly. Then the wound surface was covered with vaseline gauze and then covered with sterile gauze; finally, the adhesive tape or bandage were used to fix once a day. Clinical efficacy, chemotherapy duration, hospitalization time and hospitalization cost were compared between 2 groups after 2 weeks of treatment. RESULTS： The total effective rate of trial group （92.11%） was significantly higher than in control group （73.68 % ） ; there was statistical significance （22= 4.547, P= 0.033）. Chemotherapy duration, hospitalization time and hospital costs were （33.72 ± 4.12） d, （40.49 ± 5.13） d and （2.63 ± 0.27） ten thousand yuan in trial group, which were significantly lower than （37.58 ± 4.56）d, （43.35 ± 5.40）d and （2.86 ± 0.32） ten thousand yuan in control group （P〈0.05） ; there was statistical significance. CONCLUSIONS： Dermlin has a good effect on skin injury of the neck in throat cancer patients accepted ra diotherapy. It contributes to receiving continuous radiotherapy, reducing hospitalization time and hospitalization cost.
出处
《中国药房》
CAS
CSCD
2013年第18期1691-1692,共2页
China Pharmacy
