摘要
目的探讨卡前列甲酯栓预防产后出血的应用价值及时机。方法选择2010年5月至12月于本院住院分娩的产妇200例为研究对象。使用双盲、随机法,将其分为3组,卡前列甲酯栓产前组(产前组,n=60)、卡前列甲酯栓产后组(产后组,n=60)和对照组(n=60),3组产妇在年龄、孕周、体重等方面比较,差异无统计学意义(P>0.05)(本研究遵循的程序符合本院人体试验委员会制定的伦理学标准,得到该委员会批准,分组征得受试对象的知情同意,并与之签署临床研究知情同意书)。产前组于第2产程末胎头已着冠,约1～2个宫缩娩出时经肛门置入1mg卡前列甲酯栓;产后组于胎儿娩出后立即给予上述相同处理;对照组于胎儿娩出后立即经腹壁子宫体注射20U缩宫素。比较3组产妇的第3产程持续时间和产后出血量等。结果产前组的第3产程时间持续时间明显短于产后组和对照组(P<0.01),且产后2h,24h出血量较另2组明显减少。3组用药前、后,收缩压和舒张压变化比较,差异无统计学意义(P>0.05)。应用卡前列甲酯栓的120例产妇中,共计13例(10.83%)出现不良反应,其中,8例(6.67%)为头痛、轻微恶心;5例(4.17%)为腹泻,均未经特殊处理自行缓解。3组患者中均未发生新生儿窒息。结论卡前列甲酯栓在产前应用可有效预防产后出血的发生。
Objective To study the application value and clinical effects of Methyl carprost suppository in the prevention of postpartum bleeding. Methods From May to December 2010, a total of 200 full-term pregnant women were included into this study. They were divided into three groups according to prospective randomized point method, antepartum group （n = 60）, post-partum group （n = 60） and control group （n = 80）. Antepartum group were given anal drugs in 1-2 uterine contractions before childbirth, post-partum group were given the same treatment after fetal childbirth, and control group were given 20 U oxytocin uterine injection after fetal child birth. The bleeding amounts of the third stage labor and postpartum were compared. The study protocol was approved by the Ethical Review Board of Investigation in Human Being of the 2nd Affiliated Hospital of Kunming Medical University. Informed consent was obtained from all participates. Results The duration of third stage labor of antepartum group was significantly shorter than that of post-partum group and control group （P〈 0. 01）, and postpartum amount of bleeding was much less than that of other two groups. There had no significant difference of blood pressure change among three groups （P〉0.05）. The incidence rate of side-effect of antepartum group and post-partum group was 10. 830/00 （13/120）, including 8 cases with headache, and 5 cases with diarrhea. Conclusions Prenatal application of Methyl carprost suppository can effectively prevent the occurrence of postpartum bleeding.
出处
《中华妇幼临床医学杂志（电子版）》
CAS
2013年第2期180-183,共4页
Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition)
关键词
产后出血
卡前列甲酯栓
预防
postpartum bleeding
Methyl carprost suppository
prevention
