3MANTZ J. Alpharadrenoceptor agonists: analgesia, sedation, anxiolysis, haemodynamics, respiratory function and weaning [J]. Bailliere's Clin Anaesthesiol, 2000, 14(2): 443-448.
4ANTTILA M, PENTTILA J, HELMINEN A, et al. Bioavailability of dexmedetomidine after extravascular doses in healthy subjects [J]. Br J Clin Pharmacol, 2003, 56(6) : 691-693.
5KAROL MD, MAZE M. Pharmacokinetics and interaction pharmacodynamics of dexmedetomldine in humans [J]. Bailliere's Clin Anaesthesiol, 2000, 14(2): 261-269.
6KAMIBAYASHI T, MAZE M. Clinical uses of α2-adrenergic agonists[J]. Anesthesiology, 2000, 93(5) : 1345-1349.
7LAKHLANI PP, MacMILLAN LB, GUO TZ, et al. Substitution of a mutant alpha2a-adrenerglc receptor via "hit and run" gene targeting reveals the role of this subtype in sedative, analgesic, and anesthetic-sparing responses in vivo[J]. Proc Natl Acad Sci USA, 1997, 94(18): 9950-9955.
8MAKARITSIS KP, JOHNS C, GAVRAS I, et al. Role of alpha (2)-adrenergic receptor subtypes in the acute hypertensive response to hypertonic saline infusion in anephric mice [J]. Hypertension, 2000, 35(2): 609-613.
9SALLINEN J, HAAPALINNA A, VIITAMAA T, et al. Adrenergic alpha2C-receptors modulate the acoustic startle reflex, prepulse inhibition, and aggression in mlce[J]. J Neurosci, 1998, 18(8) : 3035-3042.
10AANTAA R, JAAKOLA ML, KALLIO A, et al. Reduction of the minimum alveolar concentration of isoflurane by dexmedetomidine[J]. Anesthesiology, 1997, 86(5) : 1055-1060.
8Kim YS, Kim YI, Seo KH, et al. Optimal dose of prophylactic d- exmedetomidine for preventing postoperative shivering [ J ]. Int J Med Sci,2013,10(10) :1327 - 1332.
