摘要
脑的老化表现为记忆力的减退。脑老化的钙假说认为脑的老化与中枢神经系统 [Ca2 +]i的调节机制紊乱有关 ,衰老可以通过多种因素导致 [Ca2 +]i 升高 ,影响突触传导 ,神经递质释放 ,信号转导等导致记忆障碍 。
Brain aging is associated with a marked decline of memory. The calcium homeostasis imbalance hypothesis postulated that sustained changes in the regulation of intracellular Ca 2+ concentration, [Ca 2+ ] i are the major cause of brain aging .Aging may cause the increase of the [Ca 2+ ] i through many mechanisms. These alterations would in turn affect the synaptic transduction, neurotransmitter release and signal transduction, cause memory deficit. This article reviewed the progress about this hypothesis in recent years.
出处
《生理科学进展》
CAS
CSCD
北大核心
2000年第2期102-108,共7页
Progress in Physiological Sciences
基金
国家重点基础研究发展规划项目! (973)
关键词
脑老化
钙稳态
迟后超级化
Ca^2+结合蛋白
Brain aging
[Ca 2+ ] i homeostasis
After hyperpolarization
Ca 2+ binding protein
Protein kinase C
