摘要
神经突触在生长发育、可塑性及突触间的信息传递过程中涉及一个重要的机制:长时程增强和长时程抑制,该机制在学习记忆方面起着至关重要的作用。而NMDA受体与长时程增强机制有着密切的关系:NMDA受体通过改变受体亚基比例、介导一氧化氮及其酶、影响离子通道的开放状态以及其他方面的因素介导长时程增强机制的诱导及维持,进而影响神经突触间的信号传递。
An important mechanism is invovled in the growth and development,plasticity and transmission of synapses：long-term potentiation and long-term depression,which plays a crucial role in learning and memory.NMDA receptors are closely related to the long-term potentiation：NMDA receptors mediate the induction and maintain long-term potentiation through changing the proportion of receptor subunits,mediating NO（nitric oxide）and its enzymes,affecting the open state of ion channels and other aspects,and then affect the signals transmission between the nerve synapses.
出处
《医学综述》
2011年第16期2424-2426,共3页
Medical Recapitulate
关键词
NMDA受体
突触传导
长时程增强
突触可塑性
NMDA receptors
Synaptic transmission
Long-term potentiation
Synaptic plasticity
