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呼吸道合胞病毒毛细支气管炎患儿血清IFN-γ、IL-17、IgE水平变化及意义 被引量:10

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摘要 目的观察呼吸道合胞病毒(RSV)毛细支气管炎(毛支)患儿血清IFN-γ、IL-17、IgE水平变化,并探讨其意义。方法受检对象81例,其中RSV毛支组46例、病毒性肺炎组20例、对照组(体检健康婴儿)15例;RSV毛支组分为轻症毛支组24例和重症毛支组22例;病毒性肺炎组及对照组患儿RSV抗原检测均为阴性。采用ELISA法测定各组血清IFN-γ、IL-17,化学发光法测定血清IgE。结果与病毒性肺炎组及对照组相比,RSV毛支组血清IL-17、IgE水平明显升高(P均<0.05),而IFN-γ水平则明显降低(P均<0.01)。与对照组相比,病毒性肺炎组血清IL-17水平明显升高(P<0.01)。与重症毛支组相比,轻症毛支组血清IL-17、IgE水平明显降低(P均<0.05),而IFN-γ水平则明显升高(P<0.01)。RSV毛支组IL-17水平与IgE水平呈正相关(r=0.339,P<0.05),与IFN-γ水平呈负相关(r=-0.417,P<0.01)。结论 RSV毛支急性期患儿血清IL-17、IgE水平升高,IFN-γ水平降低。IL-17血清水平能反映患儿病情的严重程度并提示辅助性T细胞(Th)17功能亢进。
机构地区 聊城市人民医院
出处 《山东医药》 CAS 2013年第15期73-75,共3页 Shandong Medical Journal
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