摘要
目的:分析O型孕妇血型抗体效价与新生儿溶血病之间的关系。方法:选择2000例丈夫血型非O型的O型孕妇血清,采用微柱凝胶技术检测血清中的IgG-抗体效价;对孕妇生产的新生儿在出生后进行新生儿溶血病3项试验(直抗试验、游离试验和释放试验)和新生儿胆红素、血红蛋白的检测,以评价O型孕妇血型抗体效价与新生儿溶血病之间的关系。结果:2000例O型孕妇血清中IgG-抗A(B)效价≥64的孕妇共1204例(60.2%);孕妇血型抗体效价越高,发生新生儿溶血病的概率越大(P<0.05)。结论:孕妇血型抗体效价的检测对新生儿溶血病的早期诊断提示作用明确,可作为新生儿溶血病的筛查指标,临床应广泛开展对O型孕妇的产前IgG-抗A(B)效价检查。
Objective：To explore the relationship between the IgG blood group antibody titer in the pregnant women with blood type O and hemolytic disease of newborn. Method： IgG blood group antibody titer of 2 000 pregnant woman with blood type O was detected by microcolumn gel technique. Direct antiglobin test,indirect antiglobulin test and elution test were performed in the newborns. Bilirubin and hemoglobin level of newborn infants were tested with routine methods. The relationship between the IgG blood＇group antibody titer of pregnant women with blood type O and hemolytic disease of newborn were studied. Result：Among 2 000 pregnant women with blood type O, IgG anti-A（B） blood group antibody titers of 1204 pregnant women were^64 （60.2%）. The rate of hemlytic disease of newborn was increased with the higher IgG blood group antibody titer in serum of pregnant women. Conclusion：Detecting of the IgG blood group antibody of pregnant women would be helpful to diagnose hemolytic disease of newborn,and could be used to reduce the incidence of hemolytic disease of newborn.
出处
《临床血液学杂志（输血与检验）》
CAS
2013年第2期217-218,221,共3页
Journal of Clinical Hematology(Blood Transfusion & Laboratory Medicine)
关键词
血型抗体
效价
新生儿溶血病
微柱凝胶技术
blood group antibody
titer
hemolytic disease of newborm microcolumn gel technique
