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丘脑底核脑深部电刺激治疗特发性震颤2例临床分析 被引量：2

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摘要 目的虽然丘脑腹中间核(Vim)是治疗特发性震颤(ET)首选靶点,但是由于存在刺激耐受和其他副作用,因此需要探索新靶点。本文旨在探讨丘脑底核(STN)脑深部电刺激治疗ET的可能性。方法回顾性分析2例在北京天坛医院接受丘脑底核脑深部电刺激的ET病人的资料。病人接受立体定向手术,根据神经解剖图谱、术前MRI,术中微电极记录和测试以确定靶点。术后调节刺激参数以达到较好的控制效果和电池寿命。术后随访对治疗效果进行评价。结果 2例患者术中记录到典型的电信号,测试震颤明显减轻。术后震颤评分(FTMTRS)分别提高66.7%和75.5%。电极植入术后没有感染、出血、感觉异常、构音困难、认知和平衡障碍以及复视等副作用。结论丘脑底核也可以作为特发性震颤脑深部电刺激的备选治疗靶点。
作者 陈宁 孟凡刚 马羽 葛燕 张凯 胡文瀚 张鑫 张建国
机构地区 北京首都医科大学附属北京天坛医院神经外科 首都医科大学北京市神经外科研究所
出处 《立体定向和功能性神经外科杂志》 2013年第1期34-37,共4页 Chinese Journal of Stereotactic and Functional Neurosurgery
基金 北京市卫生系统高层次卫生技术人才培养计划(编号:2011-3-032)
关键词 脑深部电刺激 丘脑腹中间核 丘脑底核 特发性震颤
分类号 R741 [医药卫生—神经病学与精神病学]
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参考文献23

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二级参考文献12

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共引文献8

同被引文献78

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立体定向和功能性神经外科杂志
2013年 第1期

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