摘要
目的研究不同剂量的低渗性非离子型对比剂碘海醇对冠状动脉造影(CAG)和经皮冠状动脉介入治疗(PCI)患者肾功能的影响。方法选择我院2010年10月至2011年4月672例接受冠状动脉介入诊疗术的患者,根据对比剂用量分为2组:A组剂量<200ml,435例;B组剂量为200～400ml,237例。以术后48h血肌酐(SCr)较术前升高25%或升高44.2μmol/L(0.5mg/dl)作为对比剂肾病(CIN)的诊断标准,观察不同剂量碘海醇对肾功能的影响。结果 672例患者中55例发生CIN,发生率为8.2%,其中A组26例(6.0%),B组29例(12.2%),2组间发生率有统计学差异(P<0.05)。结论对比剂碘海醇对冠状动脉介入诊疗术患者肾功能有影响,对比剂用量≥200ml患者CIN发生率高。
Objective To investigate the influences of different dosages of Iohexol, a kind of low osmolar and nonionic contrast media, on renal function of patients undergoing percutaneous coronary intervention（PCI）. Methods From October 2010 to April 2011, a total of 672 patients undergoing CAG and PCI were recruited, and were divided into two groups according to different dosages of contrast media： group A containing 435 cases, the volume of contrast medium 〈 200 ml. group B containing 237 cases, the volume of contrast medium 200-400 ml. CIN was identified if the serum creati- nine was increased by 25% or 44. 2 p^mol/L （0. 5 mg/dL） of the baseline 48 hours aften operation. The influences of dif- ferent dosages of iohexol on renal function were analyzed. Results Among the 672 patients, CIN occurred in 55 patients and the incidence of CIN was 8.2%. presented with CIN 26 patients in group A and the incidence was 6. 0%, compared with 29 patients and 12. 2% in group B. there was remarkable difference in the incidence of CIN between the two groups （ P 〈 0. 05 ）. Conclusions Iohexo has effect on the renal function of patients undergoing PCI, and the incidence of CIN is higher in the patients receiving the volume of contrast medium ≥ 200 ml.
出处
《实用老年医学》
CAS
2012年第4期303-305,共3页
Practical Geriatrics
关键词
碘海醇
冠状动脉介入术
对比剂肾病
iohexol
percutaneous coronary intervention
contrast-induced nephropathy
