摘要
目的调查南宁市人乳头瘤病毒(HPV)感染及基因型的流行病学情况.为预防HPV感染和宫颈癌防治提供理论依据。方法采用PCR体外扩增和DNA反向点杂交相结合的DNA芯片技术进行HPV分型。结果在1789例17～71岁的就诊者中,共检测出阳性患者442例,阳性率为24.7%其中高危353例,低危89例,在HPV各亚型中高危型以HPV52为主。低危型以HPV 43为主。发病高峰年龄段为20～30岁。结论南宁地区女性宫颈HPV感染率较高,开展各型HPV检测对于HPV感染的诊断、治疗及子宫颈癌的早期发现、预防和治疗具有重要意义。
Objective ： To investigate HPV infection status and genotype of women In Nanning in order to provide theoretical basis for the prevention and treatment of the cervical cancer. Methods ： Detected for HPV DNA types by PCR and RDB. Result ： Among the 1789 patients, 442 patients were positive, the infection rate was 24. 7% and 353 were infected with HR -HPV （high risk HPV）, the others were low risk HPV. HPV52 was the most common genotype in HR - HPV. Else, HPV43 was the the most common geno- type in low risk HPV. the patients were the most in 20 - 30 years. Conclusion ： The positive rates of HPV were higher than other prov- inces in Nanning, and the determination of HPV genotypes plays an important role in early discovery, prevention and treatment of female genital tract diseases, such as condyloma acuminatum, cervical cancer and so on.
出处
《中国优生与遗传杂志》
2013年第4期27-28,共2页
Chinese Journal of Birth Health & Heredity
关键词
人乳头瘤病毒
基因分型
发生率
Human papilloma viruse
Genotyping
Incidence rate
