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瘦素受体与妊娠相关性研究进展 被引量：4

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摘要 瘦素受体由糖尿病基因(db)编码,目前存在6种亚型(a、b、c、d、e、f),广泛分布于下丘脑、脂肪、睾丸、胎盘等组织,具有不同的生物功能。瘦素与瘦素受体结合,激活信号转导路径,才能发挥其调节摄食、生殖等生物学活性。妊娠期瘦素浓度和功能与正常妊娠、妊娠特有疾病紧密相关,而瘦素受体参与瘦素作用调节,受体的异常也将影响胚胎着床、妊娠生理过程,如导致不孕、流产、妊娠期高血压疾病等,给母儿健康带来严重危害。
作者 王亚男 李真 校审
机构地区 第三军医大学新桥医院妇产科
出处 《中国优生与遗传杂志》 2013年第4期8-10,共3页 Chinese Journal of Birth Health & Heredity
基金 国家自然科学基金资助项目(基金编号30973203)
关键词 瘦素 瘦素受体 正常妊娠 病理妊娠
分类号 R714.1 [医药卫生—妇产科学]
  • 相关文献

参考文献27

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二级参考文献21

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中国优生与遗传杂志
2013年 第4期

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