摘要
目的了解成人大骨节病(KBD)患者血清中硒和氟的含量及其与大骨节病分度的相关性。方法 2008年8月-2009年10月,采集四川阿坝壤塘县大骨节病区成人KBD患者血清标本37例,四川非大骨节病区健康成人血清39例作为对照组。血清硒的含量采用石墨炉原子吸收分光光度法进行检测,氟采用氟离子选择电极法进行检测。统计学分析组间差异有无统计学意义,同时分析硒和氟的表达水平与大骨节病分度的相关性。结果大骨节病组患者血清硒的表达水平明显低于健康对照组(P<0.05);血清氟的表达水平虽略低于健康对照组,但无统计学意义(P>0.05)。大骨节病组患者Ⅰ度和Ⅱ、Ⅲ度间硒和氟的表达水平无统计学差异(P>0.05)。结论成人大骨节病患者血清中硒水平偏低,血清氟水平与健康人无统计学差异;血清硒和氟含量与大骨节病的分度并无明显相关性。
Objective To detect the serum levels of selenium and fluorine in patients with Kashin-Beck disease（KBD）.Methods A total of 76 adult serum samples were collected between August 2008 and October 2009,which were divided into the KBD group（n=37） in KBD-prevalent areas and a healthy control group in non-KBD area（n=39）.Serum levels of selenium were determined by graphite furnace atomic absorption spectrometry and serum levels of fluorine were determined by fluorion selective electrodes.The results were compared between the KBD and control group and among the patients with different grades of KBD as well.Results The serum levels of selenium in the KBD group were significantly lower than that in the healthy adult group（P0.05） and fluorine levels in the KBD group were similar to that in the healthy adult group（P0.05）.There was no difference in the levels of selenium and fluorine among the different grades of KBD.Conclusions The serum level of selenium in adult patients with KBD is lower than the normal ones but that of fluorine is normal.In addition,the serum levels of selenium and fluorine are not associated with the KBD grades.
出处
《华西医学》
CAS
2013年第2期221-223,共3页
West China Medical Journal
基金
"十一五"国家科技支撑计划(2007BAI25B04)~~
关键词
大骨节病
血清
硒
氟
Kashin-Beck disease
Serum
Selenium
Fluorine
