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组蛋白去甲基化酶JMJD1A及其生物学功能研究进展 被引量：2

Histone demethylase JMJD1Aand its biological functions
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摘要 组蛋白去甲基化酶JMJD1A(Jumonji do-main containing 1A)通过羟基化作用使组蛋白赖氨酸去甲基而参与转录调节,参与精子生成、能量代谢、干细胞调控,与肿瘤的发生和发展相关,是潜在的抗肿瘤药物的作用靶点。本文就JMJD1A的结构、催化反应机理、底物特异性、生物学功能和抑制剂作一综述。 Histone demethylase JMJD1A （Jumonji domaincontaining protein 1A） regu- lates gene transcription by hydroxylation path- way, which demethylases mono- and di-methy H3K9 （H3Kgmel/2）. JMJD1A play roles in spermatogenesis, energy metabolism, regulation of stem cell as well as the initiation and progressof cancer. Here, we review the structure, cata- lytic mechanism, substrate specificity, biological function and inhibitor of JMJD1A.
作者 湛敏 周宏灏
机构地区 中南大学临床药理研究所
出处 《中国临床药理学与治疗学》 CAS CSCD 2013年第3期325-330,共6页 Chinese Journal of Clinical Pharmacology and Therapeutics
关键词 JMJD1A 基因转录调控 组蛋白去甲基化酶 JMJDIA Histone demethylase Gene transcriptional regulation
分类号 R969.8 [医药卫生—药理学]
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二级参考文献46

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中国临床药理学与治疗学
2013年 第3期

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