摘要
纳米粒载药系统可以改变药物的体内分布特征,具有缓控释和靶向给药特性,增加药物的稳定性,提高药物的生物利用度。纳米粒的靶向选择性可以通过增强渗透滞留效应(EPR)、偶联特定的配体,或由于生理条件如pH值、温度等的改变实现。纳米粒可以由多种材料制备并且用于包合各种化学治疗药物以降低药物不良反应,其中,磁性纳米粒作为抗肿瘤药物载体不仅可以用来治疗还能用于成像诊断。本文综述了纳米粒被动靶向、主动靶向、物理化学靶向给药系统用于抗肿瘤药物载体的研究进展。
A nanoparticle drug carrier system that can change the characteristics of drug distribution in vivo has sustained and controlled release features as well as targeted drug delivery. The system can increase the stability of the drug and raise drug bioavailabil- ity. The selective targeting of nanoparticle （NPs） can be achieved through enhanced permeability and retention effect and a conjugated specific ligand or through the effects of physiological conditions, such as pH and temperature. Nanoparticles can be prepared using a wide range of materials and can be used to encapsulate chemotherapeutic agents to reduce toxicity with which the magnetic nanoparti- cles as the anticancer drug carrier can be used for imaging, therapy, and diagnosis. In our study, we reviewed recent progress on nanoparticles as a targeted drug delivery system, including positive-targeting, negative-targeting, and physicochemical-targeting used as anticancer drug carrier.
出处
《中国肿瘤临床》
CAS
CSCD
北大核心
2013年第6期363-366,共4页
Chinese Journal of Clinical Oncology
基金
广州市重大科技专项计划项目(编号:2008A1-E4101)资助~~
关键词
纳米粒抗肿瘤药物
药物载体
nanoparticles, anticancer drugs, drug carrier
