摘要
[目的]探讨欣胃颗粒治疗慢性萎缩性胃炎(CAG)的疗效及其机制。[方法]采用100μg/ml甲基硝基亚硝基胍(MNNG)自由饮用,0.3g/kg雷尼替丁喂养,配合饥饱失常等综合方法进行造模,3个月制成大鼠CAG模型。设正常、模型、维酶素组及欣胃颗粒高、中、低剂量治疗组,观察大鼠胃黏膜病理形态学及胃液pH变化。[结果]各药物治疗组大鼠胃黏膜均有不同程度改善,欣胃颗粒高、中、低剂量组与模型组、维酶素组比较,pH值明显降低(P<0.05,或<0.01)。[结论]欣胃颗粒通过改善胃黏膜的病理形态,从而促进胃酸分泌治疗CAG。
[Objective]To explore the effect of Xinwei Granule（XG） in treating chronic atrophic gastritis （CAG） and its mechanism. [Methods]100μg/ml methyl nitrate phosphite nitroguanidine （MNNG） was given to rats for free drinking,which contains 0. 3 g/kg zantac. Irregular diet was also applied for 3 months to help establish CAG rat model.. The grouping was as follows： normal group, model group, Weimeisu group, and Xinwei Granule of high, middle, and low dose treatment groups. The pathological morphology of gastric mucosa and pH changes of gastric fluid were observed. [Results]The pH value decreased obvious- ly in XG groups of all doses compared to Weimeisu group and model group （P〈0.05,or P〈0.01）. [Con- clusion]Xinwei Granule can improve the gastric mucosal pathological morphology so as to promote the gas- tric acid secretion, thus is effective in the treatment of CAG.
出处
《中国中西医结合消化杂志》
CAS
2013年第3期120-121,共2页
Chinese Journal of Integrated Traditional and Western Medicine on Digestion
基金
国家自然科学基金项目(81072774)
黑龙江中医药大学校基金资助项目(X200905)
关键词
欣胃颗粒
胃炎
慢性萎缩性
维酶素
胃液pH
Xinwei Granule
chronic atrophic gastritis
Weimeisu
gastric pH value
