摘要
目的:观察丙氨酰谷氨酰胺联合早期肠内营养对重症急性胰腺炎营养状况和免疫功能的影响。方法:将40例患者随机分为两组,即常规肠内营养组(对照组)和谷氨酰胺强化的肠内营养组(治疗组)。进行APACHE Ⅱ评分,并检测患者第1天、治疗后第7天、第14天的CD3+、CD4+、CD8+及CD4+/CD8+,同时监测白蛋白(ALB)、转铁蛋白(TF)及氮平衡(NB)等营养代谢指标。结果:两组治疗后CD3+、CD4+、CD8+及CD4+/CD8+比值均较治疗前逐渐升高(均P<0.05),且治疗组的上述各指标在治疗后第7、14天均显著高于对照组(均P<0.05)。两组治疗后ALB和TF显著升高(均P<0.05),负氮平衡转为正氮平衡(P<0.05);治疗组的ALB和TF在治疗后第7天、第14天均显著高于对照组(均P<0.05)。结论:早期肠内营养与谷氨酰胺联用可明显改善重症急性胰腺炎患者的营养和细胞免疫状况。
Objective： To investigate the effects of early enteral nutrition（EEN） and glutamine -supplemented EEN on the immune function and nutritional metabolism in old patients with severe acute pancreatitis.Methods： 40 patients were randomly divided into two groups, normal enteral nutrition group（control group） and glutamine-supplemented EEN group（experimental group）.APACHE Ⅱ score was used to evaluate the patients after admission. Blood samples were colleeted on day 1, 7, 14 after admission for Tlymphoeyte subsets; Meanwhile, the albumin（ALB）, transferring（TF） and nitrogen balance（NB） were also measured.Results： C D3＋, CD4＋, CD8＋ value and CD4＋/CD8＋ ratio in both two groups were significantly higher after treatment than that before treatment（P〈0.05）, and the values of experimental group on day 7, 14 after treatment were significantly higher than control group after treatment（P〈0.05）. ALB and TF were significantly increased in two groups after treatment（P〈0.05）, negative nitrogen balance converted to positive nitrogen balance（P〈0.05） ; ALB and TF values of experimental group on day 7, 14 after treatment were significantly higher than control group after treatment.Conclusion： Glutamlne-supplemented EEN can obviously improve the immune function and nutritional metabolism in old patients with severe acute pancreatitis.
出处
《中外医学研究》
2013年第10期3-4,共2页
CHINESE AND FOREIGN MEDICAL RESEARCH
