摘要
目的:探讨肥胖对急性重症胰腺炎严重程度的影响,并探讨其初步机制。方法:分析我院急性胰腺炎患者128例,根据体重指数(BMI),分为肥胖组(BMI≥28 kg/m2)和非肥胖组(BMI<28 kg/m2),比较两组患者病情严重程度、并发症发生情况及入院24h内血清白细胞介素-6(IL-6)、C反应蛋白(CRP)、肿瘤坏死因子-α(TNF-α)水平。结果:肥胖组中急性重症胰腺炎患者比例显著高于非肥胖组(P<0.05),肥胖组中胰腺坏死、胰腺脓肿、胰腺假性囊肿、肺功能衰竭发生率及死亡率显著高于非肥胖组(P<0.05)。而且肥胖组炎症因子IL-6、CRP和TNF-α水平显著高于非肥胖组(P<0.05)。结论:肥胖是影响急性胰腺炎患者病情严重程度的重要因素,其机制可能与扩大的炎症反应有关。
Objective.To investigate the effects of obesity on the severity of acute pancreatitis and explore its rudimentary mechanism.Methods：Data were collected from 128 consecutive patients with acute pancreatitis （AP）,BMI was categorised as non-obese（BMI〈28kg/m^2） ,and obese（BMI≥28 kg/m^2）,The severity and the rates of complications in above mentioned two groups were compared,respectively.The serum lever of interleukin-6 （IL-6） ,C-reactive protein （CRP） and tumor necrosis factor-α （TNF-α） were detected.Results：The percentage of patients with severe AP in obese group was higher than that in non-obese group（P〈0.05）.The rates of occurence of pancreatic necrosis,pancreatic pseudocyst,respiratory failure and mortality in obese group were higher than those in non-obese group（P〈0.05）.The serum level of IL-6,CRP and TNF-αn obese group were significantly higher than the non-obese group （P〈0.05）.Conclusion：Obesity increased the severity of AP,which may be related to the expansion of inflammatory response in obese patients.
出处
《中日友好医院学报》
2007年第2期88-90,共3页
Journal of China-Japan Friendship Hospital
