摘要
目的：观察新型抗胆碱药长效托宁治疗急性有机磷农药中毒的效果。方法：急性有机磷农药中毒患者随机分为长效托宁治疗组与阿托品对照组，采用推荐剂量按轻、中、重分组治疗，并对其治疗效果进行比较。结果：长效托宁对不同中毒程度患者毒蕈碱样症状的控制疗效确实可靠，与对照组相比，达到阿托品化时间无明显差异（Ｐ＞０． ０５），但血清组织释放酶酶峰值、住院时间、住院费用及用药过量发生率均显著降低（Ｐ＜０ ．０５），尤其是给药次数极显著地减少（ Ｐ＜０． ００１）。对有机磷中毒昏迷病人昏迷时间及因胆碱能危象所致呼吸衰竭病人呼吸恢复时间均明显缩短（Ｐ（０ ．０５）。结论：长效托宁是救治急性有机磷农药中毒较为理想的抗胆碱药。
Objective: To observe the effect of the new cholinolytic-long effective Tuoning on the treatment of acute organophosphorus pesticides poisoning. Methods: Patients with acute organophosphorus pesticides poisoning were divided randomly into two groups. Group Ⅰ were treated with long effective Tuoning and Group Ⅱ with atropine. Different doses were recommended depending on mild, moderate and severe degree the rapeutic effects were then compared. Results: The effect of long effective Tuoning was evident in various seventies of poisoning in controlling muscarinic symptoms. Compared with the control group, the time needed for the atropinization of the treatment group showed no difference (P >0. 05). The peak values of serum enzyme,course of disease, hospitalization expense and incidence of overdose in the treatment group differed markedly (P < 0. 05 ), from the control group especially the times of giving drugs(P < 0. 001 ). The course of organophosphoric coma and respiratory failure which caused by cholinergic crisis shortened markedly too (P < 0. 05). Conclusion: Long effective Tuoning is an ideal cholinolytic to acute organophosphorus pesticides poisoning.
出处
《中国临床医学》
2000年第3期294-296,共3页
Chinese Journal of Clinical Medicine
