摘要
目的研究胃癌患者红细胞免疫功能与神经内分泌变化的相关性。方法采用花环法检测了２２例胃癌患者手术前后及２０例正常体检者的红细胞免疫粘附功能，同时采用放免法测定其血浆β－内啡肽的水平，并探讨它们之间的相互关系。结果胃癌患者β－内啡肽水平较正常组显著升高，血浆β－内啡肽水平与肿瘤红细胞花环率、红细胞Ｇ_３ｂ受体花环率呈显著负相关。结论胃癌患者红细胞免疫功能可能受神经内分泌系统的调控，且与血浆β－内啡肽的水平呈显著负相关，β－内啡肽对红细胞免疫功能可能起抑制作用。
Objective To investigate the correlation between the erythrocyte immune function and the neuroendocrine in the patients with gastric carcinoma. Methods The erythrocyte immune function and the level of plasma β-endorphin were detected at the same time. Results The plasma β-endorphin level of patients with gastric carcinoma was much higher than that of health persons, and there was a significant negative correlation between the level of 3-endorphin and TRR (red blood cell tumor ring rate), and RCR (red blood cell C_3b receptor ring rate). Conclusion The erythrocyte immune function may be modulated by neuroendocrine system. β-endorphin may depress erythmeyte immune function.
关键词
红细胞免疫功能
Β-内啡肽
癌
胃肿瘤
Erythrocytic immunity function β-endorphin Gastric carcinoma
