摘要
目的探讨低频重复经颅磁刺激(rTMS)治疗精神分裂症患者顽固性幻听的临床疗效。方法选取2008年4月—2012年4月于我院就诊的80例伴顽固性幻听的精神分裂症患者,采用随机双盲对照实验方法,分为试验组(40例)和对照组(40例),对照组采用伪刺激治疗,试验组采用rTMS治疗,共持续6周。采用阳性和阴性症状量表(PANSS)、幻听量表(AHRS)和临床疗效总印象量表(CGI)评估病情与疗效。结果试验组治疗后的幻听、PANSS阳性症状评分、一般情况评分和总分低于对照组,差异有统计学意义(P<0.05),阴性症状相比无统计学差异(P>0.05)。试验组治疗后的AHRS评分和CGI评分低于对照组,差异有统计学意义(P<0.05)。在治疗期间,没有患者因无法耐受不良反应而终止试验。结论 rTMS治疗精神分裂症患者顽固性幻听可以显著减轻患者精神分裂症状,改善其幻听症状,疗效确切。
Objective To observe the clinical effect of low frequency repetitive transcranial magnetic stimulation （rTMS） on audi- tory hallucination in patients with schizophrenia. Methods A total of 80 patients with schizophrenia, treated in our hospital during April 2008 and April 2012, were randomly divided into two groups （ n = 40/group） by a randomized double-blind controlled method. Control group was given shame stimulation correspondingly and trial group was given true rTMS for six weeks. All the patients were evaluated with PANSS, AHRS and CGI before and after treatment. Results The auditory hallucinations,POS and GEN scores of the trial group were significantly lower than that of the control group, the difference had statistical significance （ P 〈 0.05 ）. The NEG scores of the two groups had no significant difference （ P 〉 0.05 ）. The AHRS and CGI scores of the trial group were signifi- cantly lower than that of the control group after treatment （ P 〈 0.05 ）. During the experiment, no patients was unable to tolerate the adverse reactions. Conclusion To use low frequency rTMS in treatment of auditory hallucination in patients with schizophrenia can significantly reduce the symptoms of schizophrenia and improve their auditory hallucinations. It is clinicailv effective.
出处
《临床军医杂志》
CAS
2013年第3期275-277,共3页
Clinical Journal of Medical Officers
关键词
重复经颅磁刺激
精神分裂症
幻听
repetitive transcranial magnetic stimulation
schizophrenia
auditory hallucination
