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响应面分析法优化甘油催化生产1,3-二羟基丙酮 被引量：1

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摘要 对弗托氏葡萄糖酸杆菌(Gluconobacter frateurii)HD924发酵生产1,3-二羟基丙酮(DHA)发酵培养基进行优化。单因素试验结果表明,培养基中CaCO3、玉米浆和甘油浓度对发酵影响显著,利用响应面分析法对培养基成分进行优化,并建立了各因素与DHA产量之间的数学模型。在CaCO32.14 g/L、玉米浆23.26 g/L、甘油106.85 g/L条件下,二羟基丙酮最大估计值为82.09 g/L,优化后的DHA产量比优化前提高了25.76%,与响应面预测极值基本相符。
作者 孙杨 刘宇鹏 李华 靳魁奇
机构地区 河南大学生命科学学院生物工程研究所
出处 《江苏农业科学》 北大核心 2013年第3期223-226,共4页 Jiangsu Agricultural Sciences
基金 河南大学青年骨干教师培养计划 长兴制药有限公司横向委托项目(编号:H201215)
关键词 弗托氏葡糖杆菌 甘油 1 3-二羟基丙酮 响应面分析法
分类号 Q815 [生物学—生物工程]
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二级参考文献47

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共引文献22

同被引文献18

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江苏农业科学
2013年 第3期

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