摘要
目的:探讨环形电切术(LEEP)治疗宫颈上皮内瘤变(CIN)的效果。方法:对2009年1月～2012年1月承德市妇幼保健院经病理检查明确诊断为宫颈上皮内瘤变的415例患者进行LEEP术治疗,分别于术后3、6、9、12个月进行液基细胞学检查(TCT)、DNA细胞学定量分析及阴道镜下病灶活检,并对患者进行1～2年的随访。结果:415例患者中,宫颈光滑和轻度柱状上皮异位84例,占20.24%;中重度宫颈柱状上皮异位331例,占79.76%;415例术后均无CIN残留及复发,术后6～12月TCT异常6例,DNA细胞学定量分析倍体异常13例,术后12月治愈率94.88%,术后345例患者性感觉无变化,44例性生活无不适感,15例性生活疼痛,术后70例有生育要求患者随访24～36月,妊娠65例,异位妊娠2例,流产7例,早产9例,足月分娩41例。结论 :LEEP术治疗宫颈CIN安全有效,对性生活及妊娠未见明显影响。
Objective：To explore the curative effect of loop electrosurgical excision procedure（LEEP） for treatment of 415 cases with cervical intraepithelial neoplasia（CIN）.Methods：A total of 415 patients who were diagnosed as CIN definitely by pathological examination in the hospital from January 2009 to January 2012 were treated with LEEP,then Thin Prep cytologic test（TCT） was conducted at 3,6,9,and 12 months after LEEP,DNA cytological quantitative analysis and colposcopic biopsy were conducted,all the patients were followed up for 1-2 years.Results：Among 415 patients,84 patients were found with smooth cervix and mild cervical columnar ectopy,accounting for 20.24%;331 patients were found with moderate to severe cervical columnar ectopy,accounting for 79.76%;no CIN residue and recurrence occurred in 415 patients,6 patients were found with abnormal TCT at 6-12 months after LEEP,DNA cytological quantitative analysis found 13 patients with abnormal ploidy,the curative rate at 12 months after LEEP was 94.88%,sexual sensation of 345 patients after LEEP didn＇t change,sexual life of 44 patients had no discomfortableness,sexual pain occurred in 15 patients,70 patients with reproductive demand were followed up for 24-36 months after LEEP,65 patients got pregnancy,2 patients got ectopic pregnancy,7 patients miscarried,9 patients got premature delivery,and 41 patients gave birth to their full-term babies.Conclusion：LEEP is an effective and safe method for treatment of CIN,and it has no significant impact on sexual life and pregnancy.
出处
《中国妇幼保健》
CAS
北大核心
2013年第10期1663-1665,共3页
Maternal and Child Health Care of China
关键词
宫颈环形电切术
宫颈上皮内瘤变
效果分析
Loop electrosurgical excision procedure
Cervical intraepithelial neoplasia
Effect analysis
