摘要
目的:分析妊娠合并抗磷脂综合征(antiphospholipid syndrome,APS)与各妊娠并发症及新生儿出生体重、Ap-gar评分和抗体滴度与妊娠结局的关系。方法:回顾性分析温州医学院附属第一医院2005年6月～2011年3月的11例妊娠合并抗磷脂综合征妇女的52次妊娠过程,并与随机抽取的26例非抗磷脂抗体综合征妇女的妊娠情况进行对比。结果:抗体滴度高的APS妇女的早产率明显高于抗体滴度低的APS妇女。APS组孕妇的流产率明显高于非APS组,妊娠并发症如妊娠期高血压疾病、前置胎盘、妊娠合并肝内胆汁淤积等的发病率没有显著高于非APS组,但是胎膜早破的发生率明显增高。APS组孕妇分娩的新生儿出生体重明显低于非APS组。结论:APS易导致孕妇早产及新生儿出生体重降低,危害母儿健康,故及时、合理地诊断与治疗非常重要,尤其是在抗体滴度高的APS孕妇。
Objective：To analyze the relationship between pregnancy combined with anti-phospholipid syndrome（APS）,pregnancy complications,neonatal birth weight,Apgar score,and antibody titer and pregnancy outcomes.Methods：The processes of pregnancy for 52 times in 11 pregnant women with APS from the hospital from June 2005 to March 2011 were analyzed retrospectively,then the results were compared with pregnancy situations of 26 pregnant women without APS who were selected randomly.Results：The rate of premature delivery in APS women with high antibody titer was significantly higher than that in APS women with low antibody titer.The abortion rate in APS women was significantly higher than that in non-APS women,the incidence rates of pregnancy complications（hypertensive disorder complicating pregnancy,placenta previa,intrahepatic cholestasis of pregnancy） in APS women were higher than those in non-APS women,but the incidence rate of premature rupture of fetal membrane in APS women was significantly higher than that in non-APS women.The birth weight of neonates born by APS women was significantly lower that of neonates born by non-APS women.Conclusion：APS can easily induce premature delivery of pregnant women and low neonatal birth weight,harm maternal and infantile health,so timely and reasonable diagnosis and treatment are very important,especially among APS pregnant women with high antibody titer.
出处
《中国妇幼保健》
CAS
北大核心
2013年第10期1575-1578,共4页
Maternal and Child Health Care of China
关键词
抗磷脂综合征
早产
抗体滴度
肝素
Anti-phospholipid syndrome
Premature delivery
Antibody titer
Heparin
