摘要
目的探讨肝硬化肝性脑病(HE)患者的预后相关因素。方法回顾性分析收治的84例肝硬化肝性脑病患者,将治疗后好转的36例患者作为对照组,治疗后恶化死亡的48例患者作为观察组,观察比较两组患者在感染,血氨、血肌酐、血清蛋白、血钾、血钠、甲状腺激素水平的差异。结果两组患者在胆红素异常(44.4%vs66.7%)、血钠异常(16.7%vs37.5%)、HE分期(43.6%vs25.0%)、感染(33.3%vs54.2%)等诱因比较中,差异均有统计学意义(P<0.05);在血氨异常、血清蛋白异常、血钾异常、凝血酶原时间、血肌酐异常方面差异无统计学意义(P>0.05)。Logistic回归分析显示,HE分期、Child分级、消化道出血、血钠及血肌酐均为对肝硬化患者预后具有影响的独立危险因素。结论感染等诱因的多少与肝硬化肝性脑病患者的预后密切相关,且HE分期、血肌酐、血钠是影响肝硬化肝性脑病的危险因素。
Objective To investigate the prognostic factors in the analysis of cirrhosis patients with hepatic encephalopathy（HE）. Methods Retrospective analysis was conducted on 84 cirrhosis patients with HE, 36 patients who improved after treatment were taken as the control group, the deterioration in the death of 48 patients after treatment were taken as observed group, the differences in infection, blood ammonia, serum creatinine, serum protein, serum potassium, serum sodium, thyroid hormone levels were compared between two groups. Results The patients in the comparison of bilirubin（44.4% vs 66.7%）,serum sodium（16.7% vs 37.5%）,HE stage（43.6% vs 25.0%）, infection （33.3 % vs 54.2 %）, and other incentives factors showed significant difference （ P 〈 0.05）;the difference of blood ammonia, serum protein, serum potassium, prothromhin time and serum creatinine showed no statistic significance（ P 〈 0.05）. Multivariate logistic analysis showed that HE stage, Child grade, digestive tract bleeding, serum sodium and serum creatinine may be independent risk factors for the prognosis of cirrhosis patients. Conclusion Infection and other factors in some degree is closely related with the prognosis of cirrhosis of the liver in patients with HE,and HE grade, serum creatinine,serum sodium are risk factors affecting the hepatic encephalopathy.
出处
《临床荟萃》
CAS
2013年第4期406-408,共3页
Clinical Focus
关键词
肝硬化
肝性脑病
预后
liver cirrhosis
hepatic encephalopathy
prognosis
