摘要
目的 :探讨C erbB 2和nm23基因表达与乳腺癌组织学类型、临床分期以及对乳腺癌淋巴结转移的影响。方法 :98例乳腺癌术后石腊包埋标本行免疫组化SP法。结果 :C erbB 2在淋巴结转移组表达率为60.29% ,在非淋巴结转移组表达率为33.33% ,差别有显著意义 ;C erbB 2在乳腺癌不同临床分期表达率各不相同 ,Ⅳ期为77.78 % ,Ⅱb +Ⅲ期为56.60% ,Ⅰ +Ⅱa期为25.92% ,差别有显著意义 ;C erbB 2在导管浸润癌(83.33%)、实性癌(64.41%)有过度表达。nm23基因在淋巴结转移组表达率为39.71 % ,在非淋巴结转移组表达率为76.67 % ,差别有显著意义。结论 :C erbB 2阳性表达与乳腺癌组织学类型有关 ,与淋巴结转移、临床分期呈正相关 ;nm23阳性表达与乳腺癌组织学类型、临床分期无关 ,与淋巴结转移呈负相关。
Objective:To investigate the correlation between C-erbB-2,nm23 gene expression and histological classfication,clinical stage,lymph node metastasis in breast cancer.Methods:The SP immunohistochemical method was used in 98 paraffin-embeded postoperative samples from breast cancer.Results:The rate of C-erbB-2 gene expression was 60.29% in lymph node metastases group and 33.33% in non-metastases group,there was a significant difference between the two groups.The C-erbB-2 expression was 77.78% in clinical stage Ⅳ,56.60% in Ⅱb+Ⅲ,25.92% in Ⅰ+Ⅱ a ,respectively and there was also a significant difference in the three stages.C_erbB_2 was overexpressed in ductal infiltrating cancer (83.33%)and parenchymal cancer(64.41%).The rate of nm23 gene expression was 39.71% in lymph node metastases group and 76.67% in non-metastases group,there was a significant difference in the two groups.Conclusion:The positive expression of C-erbB-2 gene was associated with histological classification and positively correlated with lymph node metastasis and clinical stage.Positive nm23 gene expression was inversely correlated with lymph node metastasis,but not related with histological classification and clinical stage.
出处
《四川肿瘤防治》
2000年第3期150-151,共2页
Sichuan Journal of Cancer Control
