摘要
目的探讨风湿性疾病湿热证的共性代谢物组特征。方法采用气相色谱-飞行时间质谱联用技术,对强直性脊柱炎(AS)湿热证患者30例、痛风性关节炎(GA)湿热证患者29例及健康志愿者44例的血清样本进行代谢组学研究,比较AS湿热证患者、GA湿热证患者相对于健康志愿者(正常组)血清中与湿热证相关的共性差异代谢物组。结果与正常组相比,α-羟基丁酸、磷酸和甘露糖在GA和AS湿热证组血清中均明显升高,而乙醇胺则明显下降。结论血清α-羟基丁酸、磷酸、甘露糖和乙醇胺可能为风湿性疾病湿热证的共性代谢物组特征。
Objective To research the common metabolomic feature of rheumatism with damp-heat syndrome. Methods A metabolomic study of serum samples was conducted in 30 ankylosing spondylitis （AS） patients with damp-heat syndrome, 29 gouty arthritis （GA） patients with damp-heat syndrome and 44 healthy volunteers by gas chromatography-time-of-flight mass spectrometry （GC-TOFMS）. The Common difference metabolomics associated with damp-heat syndrome in AS patients with damp-heat syndrome and GA patients with damp-heat syndrome were compared with the healthy volunteers. Results Compa ring with the healthy volunteers, e-hydroxy acid, phosphoric acid and mannose was significantly increased but ethanolamine was significantly decreased in AS patients with damp-heat syndrome and GA patients with damp-heat syndrome. Conclusion The common metabolomie feature of rheumatism with damp-heat syndrome may be a-hydroxy acid, phosphoric acid, mannose and ethanolamine.
出处
《中医杂志》
CSCD
北大核心
2013年第7期592-596,共5页
Journal of Traditional Chinese Medicine
基金
国家自然科学基金青年科学基金资助项目(81001488)
关键词
强直性脊柱炎
痛风性关节炎
湿热证
代谢组学
ankylosing spondylitis
gouty arthritis
damp-heat syndrome
metabolomics
