摘要
目的 探讨 p16基因的缺失表达与口腔鳞状细胞癌 (SCC)发生发展的关系。 方法 应用RT -PCR及免疫组化方法检测 30例口腔鳞癌中p16基因的缺失表达。结果 30例口腔鳞癌患者中 16例存在p16的缺失 ,缺失率为 5 3.3%。p16基因的缺失表达与口腔鳞癌的临床分期及淋巴结有无转移有关系 (P <0 .0 5 )。结论 p16基因缺失可能参与了口腔鳞癌的癌变过程 。
Objective To examine the role of retinoblastoma gene deletion in pathogenesis and progression of oral SCC.Methods RT-PCR and immunohistochemical methods were used to examine p16 gene deletion in 30 cases of oral SCC.Results 16 cases were deletion of p16 gene.The deletion rate was 53.3 %.The deletion of p16 had close relation with TNM-staging and lympho-node metastasis.Conclusion The p16 gene may be involved in carcinogenesis of SCC.Examination of p16 deletion is significant for the judgement of the malignancy and estimation of the progress of SCC.
出处
《现代口腔医学杂志》
CAS
CSCD
2000年第5期293-294,共2页
Journal of Modern Stomatology
