摘要
探讨亚慢性硝酸钐暴露对小鼠血常规指标的动态影响。ICR小鼠80只,雌雄各半,随机分成5组,分别自由饮用含硝酸钐0,5,50,500,2000 mg.L-1的水溶液90 d,在染毒后30,60,90 d分别测定血常规。雄鼠各处理组在硝酸钐暴露30,60 d后,雌鼠硝酸钐暴露60 d后WBC比对照组显著或极显著升高(P<0.05,P<0.01),但硝酸钐暴露90 d后却显著或极显著下降(P<0.05,P<0.01)。在硝酸钐暴露30,60 d后,Gr#,Ly#,MO#比对照组显著或极显著增加(P<0.05(P<0.01),但暴露90 d后无差异显著性。雌性各染毒组的RBC在硝酸钐暴露30 d显著或极显著升高(P<0.05,P<0.01),雄性2000 mg.L-1组却在硝酸钐暴露60 d后RBC显著下降(P<0.05),而硝酸钐暴露90 d对雌雄各组RBC均无影响。雌雄鼠在硝酸钐暴露30,60 d后的HGB,HCT与对照组相比分别显著或极显著升高(P<0.05,P<0.01),但暴露90 d后各组之间的HGB无显著差异,而雌鼠50,500 mg.L-1组的HCT与对照相比显著升高(P<0.05)。亚慢性硝酸钐暴露可导致小鼠血常规部分指标的改变,且与钐暴露的时间、浓度及性别相关。
To explore the dynamic effects of subchro nic exposure to Sm （NO3 ）3 on blood routine test of mice.The ICR mice were randomly divided into 5 groups （n = 16 ） and drank water containing Sm （NO3）3 at 0, 5, 50, 500, 2000 mg·1 for 90 d.The blood routine was tested at 30, 60, and 90 d fol lowing Sin（ NO3 ）3 exposure.The results showed that, compared to the same sex vehicle control, the whitecantly increased following Sm （NO3 ）3 exposure for 30 or60 d （P〈0.5, P〈0.1） but not for90 d.The red blood cell （RBC） was markedly promoted by Sm （ NO3 ） 3 exposure for 30 d in the females （ P 〈 0.5, P 〈 0.1 ） but obviously reduced by Sin（ NO3 ）3 expo sure at 2000 mg·L-1 for 60 d （P 〈0.5） in the males.The Sm（ NO3 ） 3 exposure for 30 or 60 d signifiblood cell（WBC） significantly increased in the treated male groups following Sm（ NO3 ）3 exposure for 30 or 60 d and in the treated female groups following Sm （NO3）3exposurefor60 d （P〈0.5, P〈0.1）, while WBC in both of sexes markedly reduced by Sm （NO3）3 exposure for 90 d （P 〈 0.5, P 〈 0.1）.The granulocyte count （Gr#）, lymphocyte count （Ly #）, and monocytes（MO#） in both of sex were significantly increased hemoglobin （HGB） and hematocrit （HCT） in both of sexes （P 〈0.5, P 〈0.1）, and exposure to Sin（ NO3 ） 3 at 50 and 500 mg·L-1 for 90 d markedly enhanced HCT of the females （ P 〈 0.5 ）.These results suggested that subchronic exposure to Sm （ NO3 ）3 dosage, time, and sex specifically changed blood routine test in mice.
出处
《中国稀土学报》
CAS
CSCD
北大核心
2013年第2期249-256,共8页
Journal of the Chinese Society of Rare Earths
基金
浙江省自然科学基金项目(Y5110135)资助
关键词
硝酸钐
亚慢性染毒
小鼠
血常规
稀土
nitrate samarium
sub-chronic exposure
mice
blood routine test
rare earths
