摘要
目的:探讨高尔基体蛋白73(GP73)和甲胎蛋白(AFP)在监测肝细胞肝癌(HCC)肝切除术后疗效及复发中的作用。方法:收集确诊为肝细胞肝癌并行肝切除术的患者93例,术后随访,监测患者血清GP73和AFP水平。结果:GP73和AFP血清水平与肿瘤大小、数目、有无包膜形成及包膜浸润、有无血管浸润、肝内转移以及肿瘤分化程度相关。随着GP73和AFP浓度升高,GP73和AFP诊断HCC的敏感性降低,而特异性升高。术前和术后GP73和AFP均阳性的患者6个月内肿瘤的复发率明显升高。结论:GP73和AFP是良好的监测HCC术后疗效及肿瘤复发的血清标记物。
Objective： To evaluate the role of Golgi protein 73 （GP73） and alpha fetoprotein （AFP） in monitoring the treatment response and recurrence after hepatectomy in hepatocellular carcinoma （HCC）. Methods： Serum GP73 and AFP levels were measured in 93 patients undergoing hepatec- tomy for HCC. Results： Serum GP73 and AFP levels were related to tumor size, number, capsu- lar formation and infiltration, vascular invasion, intrahepatic metastases, and tumor differentia- tion. The sensitivity of GP73 and AFP for HCC decreased, while the specificity increased accord- ing to the elevated levels of GP73 and AFP. The recurrence for HCC increased in patients that GP73 and AFP are both positive pre- or post-operation. Conclusion： GP73 and AFP are appropri- ate serum markers for monitoring the treatment response and recurrence of HCC.
出处
《武汉大学学报（医学版）》
CAS
北大核心
2013年第2期225-228,233,共5页
Medical Journal of Wuhan University
关键词
GP73
AFP
肝细胞肝癌
疗效
复发
GP73
AFP
Hepatocellular Carcinoma
Treatment Response
Recurrence
