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血清GP73在肝脏肿瘤中的表达及意义 被引量：10

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摘要 在Kladney研究发现组织中高尔基糖蛋白73（Golgi protein73，GP73）与肝炎、肝硬化、肝癌有相关性后，有学者认为GP73很可能成为诊断肝癌的新标志物。本研究初步探讨GP73在肝脏良恶性肿瘤患者的血清GP73的定量表达水平。
作者 梁冠林 廖志学 冉顺 文天夫
机构地区 四川大学华西医院肝脏血管外科
出处 《中华普通外科杂志》 CSCD 北大核心 2010年第4期339-340,共2页 Chinese Journal of General Surgery
关键词 肝脏肿瘤 血清 恶性肿瘤患者 新标志物 定量表达 糖蛋白 肝硬化 相关性
分类号 R735.7 [医药卫生—肿瘤]
  • 相关文献

参考文献9

  • 1Cassandra W.Researchers look for sweet method to diagnose cancer.Nature Med,2007,13:1267.
  • 2Maitra A,Thuluvath PJ.GP73 and liver disease:a(Golgi)complex enigma.Am J Gastroenterol.2004,99:1096-1098.
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  • 4Kladney RD,Cui X,Bulla GA,et al.Expression of GP73,a resident Golgi membrane protein,in viral and nonviral liver disease.Hepatology,2002,35:143 1-1440.
  • 5Romano PR,Nikolaeva OV,Steel L,et al.GP73,a resident Golgi membrane protein,appears in sera of patients with viral liver disease and hepatocellular cancer.Hepatology,2003,38:768A.
  • 6毛一雷,杨华瑜,徐海峰,桑新亭,卢欣,杨志英,张锦春,钟守先,黄洁夫,张宏冰.新的肝癌血清标记物GP73在肝癌诊断中的初步研究[J].中华医学杂志,2008,88(14):948-951. 被引量：132
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  • 9Iftikhar R,Kladney RD,Havlioglu N,et al.Disease-and cellspecific expression of GP73 in human liver disease.Am J Gastroenterol,2004,99:1087-1095.

二级参考文献5

  • 1Cassandra Willyard. Researchers look for ‘sweet' method to diagnose cancer. Nat Med, 2007, 13: 1267.
  • 2Kladney RD, Bulla GA, Guo L, et al. GP73, a novel golgilocalized protein upregulated by viral infection. Gene, 2000, 249 : 53-65.
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  • 5徐海峰,杨华瑜,张宏冰,毛一雷.改变肝癌早期诊断和治疗现状的新肝癌血清标志物[J].基础医学与临床,2008,28(1):104-108. 被引量：118

共引文献131

同被引文献76

  • 1孙华宝,徐龙.原发性肝癌实验室诊断及最新研究进展[J].实验与检验医学,2007,25(6):607-609. 被引量：8
  • 2杨盛力,潘晓莉.GP73的研究进展[J].肝胆外科杂志,2011,19(1):70-72. 被引量：15
  • 3Chinese Society of Hepatology and Chinese Society of Infectious Diseases,Chinese Medical Association. 42 Dongsi Xidajie,Beijing 100710,China.慢性乙型肝炎防治指南[J].中华肝脏病杂志,2005,13(12):881-891. 被引量：1927
  • 4Iftikhar R, Kladney RD, Havlioglu N, et al. Disease-and cell- specific expression of GP73 in human liver disease. Am J Gastroenterol. 2004,99 : 1087-1095.
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  • 6Marrero JA, Romnno PR, Nikolaeva O, et al. GP73, a resident Golgi glycoprotein, is a novel serum marker for hepatocellular careinoma. J Hepatol,2005,43 : 1007-1012.
  • 7MaoY,Yang H, Xu H, et al. Golgi protein 73 (G0LPH2) is a val-uable serum marker for hepatocellular carcinoma [ J]. Gut, 2010, 59(12) : 1687 -1693.
  • 8Willyard C. Researchers look for ” sweet” method to diagnose cancer[J]. Nat Med, 2007, 13 (11): 1267.
  • 9Block TM, Comunale MA,Lowman M, et al. Use of targeted glycop-roteomics to identify serum glycoproteins that correlate with liver cancerin woodchucks and humans [ J]. Procnatl Acad Sci USA,2005, 102(3): 779 -784.
  • 10WeiS,Dunn TA,Isaacs WB, et al. G0LPH2 and MY06 : putativeprostate cancer markers localized to the Golgi apparatus [ J]. Prostate,2008,68 (13) : 1387 -1395.

引证文献10

二级引证文献43

中华普通外科杂志
2010年 第4期

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