摘要
目的 评价2型糖尿病患者血糖控制水平对血脂及脂蛋白的影响.方法 随机检测2012年2月～7月就诊的2型糖尿病患者53例,其中男性30例,女性23例,分别检测糖化血红蛋白比率（HbA1c ）、C肽（C-P）、三酰甘油（TG）、总胆固醇（CHO）、高密度脂蛋白胆固醇（HDL-C）、载脂蛋白A（ApoA1）、载脂蛋白B（ApoB）及脂蛋白A（LPa）;依据HbA1c,C-P水平将其分为Ⅰ（C肽≥0.6 nmol/L及HbA1c比率＜6.0%）,Ⅱ（C肽≥0.6 nmol/L及HbA1c比率≥6.0%）及Ⅲ（C肽＜0.6 nmol/L及HbA1c比率≥6.0%）三组.结果 多元方差分析结果表明：三组间TG（F=4.33,P〈0.05）,CHO（F=6.86,P〈0.05）,ApoB（F=9.32,P〈0.001）差异均具有统计学意义,而LPa（F=0.53,P〉0.05）,ApoA1（F=1.99,P〉0.05）,HDL-C（F=5.76,P〉0.05）差异无统计学意义;调整性别、年龄因素,相关分析结果表明：ApoA1与HDL-C（r=0.75,P〈0.001）,CHO与ApoB（r=0.78,P〈0.001）分别呈正相关.结论 Lpa是2型糖尿病病情发展的独立风险因素,TG是重要影响因素.HDL-C/CHO优于HDL-C,ApoA1/CHO优于ApoA1.
Objective To evaluate the significance of the serum lipid and apolipoprotein profiles on glycemic control in patients with type 2 diabetes mellitus. Methods A total of 53 patients with type 2 diabetes （30 men,23 female） were collected in Loudi First People＇s Hospital from February to July 2012 by randomly selected, and fasting HbA1c,C-Peptide （C-P）, triglycerides （TG）, total cholesterol （CHO）, high density lipoprotein-C （ HDL-C）, apolipoprotein A1 （ApoA1）, apolipoprotein B （ApoB） and lipoprotein A （LPa） levels were measured. They were divided into three groups [group I （C-P≥0.6 nmol/L and HbAle ratio〈6.0% ） ,group Ⅱ （C-P≥0.6 nmol/L and HbA1c ratio≥6.0 %）, group Ⅲ （C-P〈0.6 nmol/L and HbA1c ratio≥6.0%）] according to C-Peptide and HbA1c levels. Results Multi-variable analyses showed there were a significant differences in TG （F=4. 33,P〈0.05） ,CHO（F=6.86 ,P〈0.05） ,ApoB （F=9.32 ,P〈0. 001） among three groups. However, there were no significant differences in LPa （F= 0. 53, P〉 0.05）, ApoA1 （F = 1.99, P〉 0.05 ）, HDL-C （ F = 5.76, P 〉0.05） among three groups. Highly significant positive correlations were observed between ApoA1 and HDL-C levels （r= 0.75, P〈0. 001） adjusted sex and age. Similarly,CHO and ApoB levels （r= 0.78, P〈0. 001） displayed a significant positive correlation. Conclusion Lpa is an independent risk factor influencing on the progression of disease with type 2 diabetes mel- litus,and the TG is an important risk factor. HDL-C/CHO ratio is a more appropriate marker of risk than HDL-C levels,and ApoA1/CHO ratio is a more appropriate marker of risk than ApoA1 levels.
出处
《现代检验医学杂志》
CAS
2013年第1期92-94,共3页
Journal of Modern Laboratory Medicine
