摘要
目的：探讨骨桥蛋白（OPN）在早期宫颈癌患者血清中的表达,以及与病理特征的关系。方法：采集60例确诊为Ⅰa~Ⅱa期宫颈癌患者及30例健康体检者的血清样本,采用酶联免疫吸附法（ELISA）测定骨桥蛋白的含量。结果：早期宫颈癌患者血清中OPN呈现高表达,明显高于健康体检患者（P〈0.05）;OPN在早期宫颈癌患者血清中的表达与肿瘤的分化程度、淋巴结转移有关（P〈0.05）,而与肿瘤的病理类型及临床分期无关（P〉0.05）。随着肿瘤的分化程度越低、淋巴结转移,OPN的血清含量越高。结论：OPN在宫颈癌的发生、发展和淋巴结转移中发挥了作用,OPN的表达水平有望作为估计宫颈癌预后的指标。
Objective：To detect the expression of OPN（osteopontin） in patients with Early Cervical Cancer,and its clinic pathological significance.Methods：Serum levels of OPN in 60 patients with Cervical Cancer stageⅠa~Ⅱa,and 30 normal women as control group were measured by ELISA.Results：The levels of OPN in Early Cervical Cancer were significantly higher than those in control group（P0.05）;The degree of expression of OPN protein in Carcinoma of cervix was relative to histologic classes and metastatic lymphonode（P0.05）,but was not relative to pathological types and the clinical stage（P0.05）.The worse histologic classes and the metastatic lymphonode,the higher serum concentration of OPN.Conclusion：OPN played an important role in the development and progression of Cervical Cancer,OPN Can be used to estimate the prognosis of Cervical Cancer.
出处
《中国医药导刊》
2013年第2期187-188,共2页
Chinese Journal of Medicinal Guide
基金
云南省卫生科技计划项目(2009NS020)
关键词
骨桥蛋白
宫颈癌
Osteopontin
Cervical Cancer
