摘要
目的:研究戊巴比妥钠和苯磺酸阿曲库铵对大鼠坐骨神经复合肌肉动作电位(compound muscle action potential,CMAP)的影响。方法:成年SD大鼠随机分为2组(n=10),戊巴比妥钠+生理盐水组(PN组)和戊巴比妥钠+苯磺酸阿曲库铵组(PA组)。2组均腹腔注射1%戊巴比妥钠40 mg·kg^(-1)麻醉,给予戊巴比妥钠8 min时PA组腹腔注射苯磺酸阿曲库铵2.5μg·kg^(-1),PN组注射等量生理盐水。而后立即刺激坐骨神经,记录其所支配的腓肠肌的CMAP。刺激强度为0.50 v,波宽0.05 ms,频率10 Hz,每隔5 min重复上述刺激。结果:PN组中,在0.5 v的刺激强度下,T18～28 min时峰峰值降低,而潜伏期延长(与T8 min时比较,P<0.05或0.01);PA组中,T18～43 min时CMAP峰峰值降低,而潜伏期延长(与T8 min时比较,P<0.05或0.01);两组比较,PA组T18～43 min时的峰峰值及潜伏期与PN组对应时间点的峰峰值及潜伏期差异有统计学意义(P<0.05或0.01)。结论:戊巴比妥钠或复合苯磺酸阿曲库铵后均可一过性抑制大鼠坐骨神经CMAP,而复合苯磺酸阿曲库后其抑制作用更强。
Objective：To study the effects of pentobarbital sodium with or without atracurium besilate on compound muscle action potential（CMAP） of sciatic nerves in rats.Method：Twenty adult SD rats were randomly divided into the PN group（pentobarbital sodium ＋ normal saline） and the PA group（pentobarbital sodium ＋ atracurium besilate） according to the random digital table.The two groups were both anesthetized by intraperitoneal injection of 1%pentobarbital sodium with the dose of 40 mg·kg^（-1）.After 8 min of the anesthesis,the rats in the PA group were intraperitoneally infused with atracurium besilate（2.5μg·kg^（-1） ）,and those in the PN group were treated by normal saline with the same volume.The two groups were stimulated sciatic nerves immediately with the stimulus intensity of 0.50 v,the width of 0.05 ms and the frequency of 10 Hz,and then repeated the above stimulation every 5 min.Result： In the PN group,CMAP peak to peak values of T18～28 min were decreased with 0.50 v intensity,and CMAP incubation periods were lengthened（compared with those of T8 min,P 0.05 or 0.01）.In the PA group,CMAP peak to peak values of T18～43 min were decreased with 0.50 v intensity,and CMAP incubation periods of T18～43 min were lengthened（compared with those of T8 min,P 0.05 or 0.01）.The peak to peak values and the incubation periods of T18～43 min of the PA group was lower and longer than these of the PN group,respectively（P 0.05 or 0.01）.Conclusion：Pentobarbital sodium with or without atracurium besilate both has transient inhibition effect on CMAP of sciatic nerves,while the inhibition effect is stronger under the combined application.
出处
《中国药师》
CAS
2013年第3期328-330,共3页
China Pharmacist
关键词
戊巴比妥钠
苯磺酸阿曲库铵
复合肌肉动作电位
监测
神经损伤
Pentobarbital sodium
Atracurium besilate
Compound muscle action potential
Monitoring
Nerve injury
