摘要
目的 研究肌松药卡肌宁对大鼠术中复合肌肉动作电位（ＣＭＡＰ） 的影响。 方法 取ＳＤ大鼠１６ 只，实验组腹腔内注射卡肌宁（１０ μｇｋｇ），对照组腹腔内注射等体积等渗盐水。于用药前、后每隔５ ｍｉｎ，刺激坐骨神经，于股二头肌记录ＣＭＡＰ，研究肌松药作用下ＣＭＡＰ潜伏期、波幅的变化规律。 结果 对照组：各时间组ＣＭＡＰ的潜伏期、波幅间均无明显改变（ Ｐ＞ ０．０５） 。实验组：ＣＭＡＰ变化可分为３ 个阶段：（１） 诱导期：表现为潜伏期逐渐延长，波幅逐渐下降，但与用药前波幅相比，下降幅度＜５０％ ，该期持续约１５～２０ ｍｉｎ；（２）抑制期：表现为ＣＭＡＰ波形消失或波幅下降，幅度＞５０％ ，该期持续约１０～１５ ｍｉｎ；（３） 恢复期：表现为潜伏期逐渐缩短，波幅逐渐增高，直至恢复用药前水平，该期持续约１５～２５ ｍｉｎ。 结论 卡肌宁对ＣＭＡＰ的影响可分为诱导期、抑制期和恢复期３ 个阶段。为正确评价神经肌肉功能状况，术中肌电检测时应争取在恢复期（ 用药后４０ ～４５ｍｉｎ）后进行。
Objective To study the effect of tracrium on compound muscle action potential(CMAP) in rats. Methods All 16 SD rats were divided into two groups. In the experiment group, tracrium (10 μg/kg) was given by intraperitoneal injection; and isotonic saline of the same volume was given to the control group. CMAP was recorded in the biceps following a stimulation at the sciatic nerve at different time, i.e. every 5 minutes before and after injection until it returned to normal. Latency and amplitude of CMAP were calculated and statistically analyzed. Results In the control group, there were no significant changes in latency and amplitude before and after injection of saline ( P >0.05). As to the experiment group, the changes of CMAP were divided into 3 stages. (1) Induction stage. The latency was gradually delayed, and the amplitude reduced. But compared with normal CMAP, the amplitude reduction rate was below 50%. The stage lasted 15 20 minutes. (2) Inhibition stage. CMAP was absent or the amplitude reduction rate was above 50%. The stage lasted 10 15 minutes. (3) Restoration stage. The latency was gradually shortened. However, the amplitude increased to normal state. The stage lasted 15 25 minutes. Conclusions The changes of CMAP in rats under the effect of tracrium can be divided into induction, inhibition and restoration stage. In order to correctly evaluate the function of neuromuscle, the intraoperative CMAP test should be performed after restoration stage(40 45 minutes).
出处
《中华创伤杂志》
CAS
CSCD
北大核心
2000年第1期14-16,共3页
Chinese Journal of Trauma
基金
卫生部重点学科基金!(CD96 - 3)
上海市领先学科基金!(95 - Ⅲ- 1)
关键词
肌肉动作电位
肌电描记术
卡肌宁
Neuromuscular nondepolarizing agents
Action potentials, muscles
Electromyography
