摘要
目的 研究全麻复合胸段硬膜外阻滞 (TEA)与否对兔实验性心肌梗死的保护作用。方法 实验组兔于气管切开插管全麻复合胸段硬膜外阻滞下开胸结扎左冠状动脉前降支 ,在不同的时段取血 ,测血浆肌酸磷酸激酶 (CK)、乳酸脱氢酶 (LDH)、谷草转氨酶 (AST)活性和一氧化氮 (NO)及超氧化物歧化酶 (SOD)活性的变化 ;对照组不作TEA ,其余处理与实验组相同。结果 实验组兔在不同时间段CK、LDH活性变化与时间关系的直线回归系数 ,相对于对照组有显著性差异 ;方差分析CK、LDH、SOD、NO模型有意义。
Objective To research the different protective effects of general anesthesia combined with thoracic epidural anesthesia on experimental myocardial infarctionMethods Rabbits of experimental group were anesthesitized with 1% sodium pentobarbitone (30 mg/kg, iv) Following tracheal intubation, epidural catheter was put into at T_ 6-7 with the anterior end of the catheter reaching at T_ 2-3 After the epidural anesthesia was made sure to be effective, the anterior descending branches of left coronary artery were ligated Blood samples were collected before ligation, 15, 30, 60, 120, 180 and 240 min after ligation All procedures of control group were similar to those of experimental group except for thoracic epidural anesthesia Nitric oxide (NO), creatine kinase(CK), lactate dehydrogenase (LDH), aspartate transaminase (AST), superoxide dismutase (SOD) were detected The changes of the activities of CK and LDH, and NO level during the research course in both groups were analyzed with liner regression Results The regression coefficients of CK, LDH and NO in the experimental group were significantly lower than those in control group In the experimental group the activities of CK and LDH decreased markedly, NO level increased significantly as compared with those in control groupConclusions General anesthesia combined with thoracic epidural anesthesia produces the protective effects on the myocardial infarction and the stress-induced injury
出处
《中华麻醉学杂志》
CAS
CSCD
北大核心
2000年第10期618-620,共3页
Chinese Journal of Anesthesiology
基金
国家教委博士点基金资助! (9743 )
关键词
全身麻醉
硬膜外麻醉
心肌梗塞
实验研究
Anesthesia,general
Anesthesia,epidural
Myocardial infarction
